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Volume 17, Issue 2 (5-2014)                   J Arak Uni Med Sci 2014, 17(2): 17-23 | Back to browse issues page

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1- Department of Antivenin and Venomous Animals, Razi Vaccine and Serum Research Institute, Karaj, Iran
2- Department of Biology, Kharazmi University, Tehran, Iran
3- Department of Cellular and Moleclar Biology, College of Biosciences, Kharazmi University,Square of University, Hesarak, Karaj, Iran , adelehoo63@gmail.com
Abstract:   (4905 Views)

Background: One of the acute effects of snakebite is injury to vital organs including kidneys. This study examines the effects of snake (Najanajaoxiana) venom on renal function.

Materials and Methods: In this experimental study, six male Dutch rabbits with average weight of 1.5± 0.3 kg were selected. Before injection of the venom, blood samples were collected for serum analysis and then the snake (Najanajaoxiana) venom (140µg/kg) was injected intramuscularly. Following venom injection, blood sampling from each rabbit was carried out at hours 1, 3, and 24. All serum samples were separated within two hours and the amounts of creatinine, urea, albumin, and glucose were determined by quantitative detection kits. Statistical analyses were carried out by SPSS software version 21. Obtained information was compared by one-way ANOVA and F and Tukey tests. p value<0.05 was considered significant.

Results: Following venom injection at hours 1, 3, and 24, some serum parameters showed slight changes which were not statistically significant. However, glucose showed a significant increase (71%) at hour 1 (p<0.05). Following venom injection, this returned to normal at hour 24.

Conclusion: Based on the results obtained in the present study, it seems that the Najanajaoxiana venom, unlike the viper species, have no severe effects on the kidney.

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Type of Study: Original Atricle | Subject: General
Received: 2013/11/26 | Accepted: 2014/03/5