Volume 21, Issue 1 (4-2018)
J Arak Uni Med Sci 2018, 21(1): 74-81 |
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Fattahzadeh M, Edalatmanesh M A. Effect of Monosodium Glutamate and L-Carnitine on Density and Structure of Granular Cells of Cerebellum in Rat . J Arak Uni Med Sci 2018; 21 (1) :74-81
URL: http://jams.arakmu.ac.ir/article-1-5417-en.html
URL: http://jams.arakmu.ac.ir/article-1-5417-en.html
1- Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
2- Department of Biology, College of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, Iran , amin.edalatmanesh@gmail.com
Abstract: (3450 Views)
Abstract
Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. The excessive use of MSG has been shown to increase oxidative stress in different regions of the brain. In this study, the neuroprotective effect of L-carnitine was investigated against MSG intoxication in granular cell of cerebellum in rats.
Materials and Methods: 48 adult male Wistar rats were randomly divided into 6 groups: the control, sham (normal saline treated), MSG (3%), L-Carnitine200, MSG+L-Carnitine100 and MSG+L-Carnitine200. After 30 days of treatment, through transcardialy perfusion, the rats were sacrificed and histopathological analyses were conducted on cerebellum.
Results: The results indicated that the density of granular cells in cerebellar folium IV, V and VI of rats in the MSG group had significantly decreased in comparison to that of the control and sham groups. Furthermore, the MSG+L-Carnitine200 group showed the higher density of granular cells compared with the MSG group in the three folia.
Conclusion: Treatment with L-Carnitine could protect the granular cells in cerebellum against MSG intoxication in rats.
Background: Monosodium glutamate (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. The excessive use of MSG has been shown to increase oxidative stress in different regions of the brain. In this study, the neuroprotective effect of L-carnitine was investigated against MSG intoxication in granular cell of cerebellum in rats.
Materials and Methods: 48 adult male Wistar rats were randomly divided into 6 groups: the control, sham (normal saline treated), MSG (3%), L-Carnitine200, MSG+L-Carnitine100 and MSG+L-Carnitine200. After 30 days of treatment, through transcardialy perfusion, the rats were sacrificed and histopathological analyses were conducted on cerebellum.
Results: The results indicated that the density of granular cells in cerebellar folium IV, V and VI of rats in the MSG group had significantly decreased in comparison to that of the control and sham groups. Furthermore, the MSG+L-Carnitine200 group showed the higher density of granular cells compared with the MSG group in the three folia.
Conclusion: Treatment with L-Carnitine could protect the granular cells in cerebellum against MSG intoxication in rats.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/10/30 | Accepted: 2018/02/7
Received: 2017/10/30 | Accepted: 2018/02/7
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