Volume 20, Issue 12 (3-2018)                   J Arak Uni Med Sci 2018, 20(12): 93-103 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hamta A, Pezeshki M, Ansari J. To Investigate the Association of Thr241Met Polymorphisms of the XRCC3 Gene with the Risk of Breast Cancer in Women in Markazi Province . J Arak Uni Med Sci 2018; 20 (12) :93-103
URL: http://jams.arakmu.ac.ir/article-1-5436-en.html
1- Department of Biology, Faculaty of Sciences, University of Arak, Arak, Iran. , A-hamta@araku.ac.ir
2- Department of Biology, Faculaty of Basic Sciences, University of Arak, Arak, Iran.
3- Department of Oncology, Ayatollah Khansari Hospital, Arak University of Medical Sciences, Arak, Iran.
Abstract:   (2732 Views)
Abstract
Background: Biological and epidemiological data suggest that damage induced by endogenous and exogenous factors affects the integrity and stability of DNA and associated with susceptibility to breast cancer. The XRCC3 protein participates in DNA double-strand breaks and recombination repair. The aim of the present study was to evaluate associations between the risk of breast cancer and Thr241Met polymorphism in the XRCC3 gene.
Materials and Methods: In this study, the effects of Thr241Met polymorphism of the XRCC3 gene and the risk of breast cancer in a population-based case-control study inclusive 80 patients and 80 healthy individuals of women in Markazi province were evaluated. Genomic DNA was extracted from blood samples using the kit procedure. The genotypes of samples were determined by PCR-RFLP technique. Statistical analysis was done using SPSS software (estimation of χ2 and p-value) and the final results were determined.
Results: Statistically significant difference was observed between the two groups of patients and controls for three genotypes of the site rs861539 (p= 0.000). Genotype CT (p= 0.000, OR=2.352, CI= 95%; 2.431 - 39.948) and TT (p = 0.003, OR= 2.352, CI=95%; 0.611 - 9.049) significant associations were showed with risk of breast cancer. Instead, the genotype CC (p= 0.000) showed a protective role against susceptibility to breast cancer.
Conclusion: This study identified that there is significant association between Thr241Met polymorphisms of the XRCC3 and the risk of susceptibility to breast cancer, which is in accordance to some of researchers' studies.

 
Full-Text [PDF 952 kb]   (1006 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2017/11/7 | Accepted: 2018/01/7

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb