Volume 21, Issue 6 (12-2018)
J Arak Uni Med Sci 2018, 21(6): 76-87 |
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Karimi N, Safari M, Roshanaei G, Poorolajal J. Determining of Factors Affecting on Mortality of AIDS Patients by Using Extended Cox Model. J Arak Uni Med Sci 2018; 21 (6) :76-87
URL: http://jams.arakmu.ac.ir/article-1-5469-en.html
URL: http://jams.arakmu.ac.ir/article-1-5469-en.html
1- Clinical Research Development Unit of Shahid Beheshti Hospital, Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Biostatistics, Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Biostatistics, Noncommunicable Diseases Reseach Center, Hamadan University of Medical Sciences, Hamadan, Iran. , gh.roshanaei@umsha.ac.ir
4- Department of Epidemiology, Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
2- Department of Biostatistics, Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Department of Biostatistics, Noncommunicable Diseases Reseach Center, Hamadan University of Medical Sciences, Hamadan, Iran. , gh.roshanaei@umsha.ac.ir
4- Department of Epidemiology, Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract: (2574 Views)
Background and Aim: Acquired immunodeficiency syndrome is caused by body contamination with human immunodeficiency virus. Several factors affect the survival of people with AIDS, which are often examined using Cox regression models. The default is to use the Cox model as a proportionate hazard, which in case of a violation, this model does not have the required performance. Therefore, the aim of this study was to determine the effective factors on survival of AIDS patients using the developed Cox model.
Materials and Methods: In this cohort study, 1050 patients with AIDS who referred to Imam Khomeini and Zamzam Behavioral Counseling Centers in Tehran Province during the years 2004 to 2014 were studied. The effect of clinical and demographic factors on survival of patients has been investigated using extended Cox model.
Findings: 79% of patients were men. The mean age of the patients was 34.84 ± 10. 21 years old. The mean of the diagnosis time to AIDS was 23.64 ± 15.53 months. 76% of patients were cencored. Age at diagnosis, transmission modes, ART, CD4 count, and time to diagnosis of AIDS in univariate and multivariate analysis were significant
(p <0.05).
Conclusion: Several clinical factors have implications for the survival of AIDS patients. The most important of these factors is the use of ART and early detection of the disease, which greatly increases the chance of survival of the affected population. Therefore, it seems necessary to provide screening and treatment services for high-risk individuals.
Materials and Methods: In this cohort study, 1050 patients with AIDS who referred to Imam Khomeini and Zamzam Behavioral Counseling Centers in Tehran Province during the years 2004 to 2014 were studied. The effect of clinical and demographic factors on survival of patients has been investigated using extended Cox model.
Findings: 79% of patients were men. The mean age of the patients was 34.84 ± 10. 21 years old. The mean of the diagnosis time to AIDS was 23.64 ± 15.53 months. 76% of patients were cencored. Age at diagnosis, transmission modes, ART, CD4 count, and time to diagnosis of AIDS in univariate and multivariate analysis were significant
(p <0.05).
Conclusion: Several clinical factors have implications for the survival of AIDS patients. The most important of these factors is the use of ART and early detection of the disease, which greatly increases the chance of survival of the affected population. Therefore, it seems necessary to provide screening and treatment services for high-risk individuals.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/11/25 | Accepted: 2018/11/12
Received: 2017/11/25 | Accepted: 2018/11/12
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