Background: Candida species are among the most important factors in development of fungal infection in human beings and animals. Noticing the daily increase of drug resistance, attempts should be made for providing anti-fungal and anti-microbial drugs. Hence, this study was conducted to investigate the in-vitro effects of Scrophularia deserti ethanolic extract and amphotricin B on Candida albicans. Materials and Methods: In an experimental trial, anti-Candida effects of Scrophularia deserti ethanolic extract and amphotricin B on Candida albicans were evaluated using serial dilution method. Data analysis was done using SPSS, through paired and independent t-tests. Results: Minimum inhibition capacity (MIC) of Scrophularia deserti extract on Candida albicans in the first and second trials were OD600=1.56(59%) and OD600=1.68(59%), respectively, whereas this value for amphotricin B was 59%. The difference between minimum growth inhibition capacity of Scrophularia deserti and amphotricin B was not significant. Conclusion: The findings of this study indicated that ethanolic extract of Scrophularia deserti has anti-fungal properties comparable to amphotricin B.

Keywords: Amphotricin B, Anti-fungal agents, Candida albicans, Scrophularia deserti

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