Write your message
Volume 22, Issue 6 (February & March 2020)                   J Arak Uni Med Sci 2020, 22(6): 182-191 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Zabihi E, Motavallibashi S E, Panahpour1 H, Sheikhkanloui Milan H. Effect of Hydroalcoholic Extract of Truffle (Terfezia Boudieri) on Serum Level of Thyroid Hormones in Male Rats. J Arak Uni Med Sci. 2020; 22 (6) :182-191
URL: http://jams.arakmu.ac.ir/article-1-6078-en.html
1- Department of Physiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
2- Department of Biochemistry, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
3- Department of Physiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. , hshmilan@gmail.com
Abstract:   (1487 Views)
Background and Aim: Thyroid gland makes thyroxine (T4) and triiodothyronine (T3) hormones. These hormones are really effective in regulating and control of basal metabolism. The purpose of this study was to assess the effect of hydroalcoholic extract of Terfezia Boundary (TB) on the serum level of thyroid hormones.
Methods & Materials: In this experimental study, 30 male Wistar rats (weighing 200±10 g) were selected and divided into five groups of 6 including control, sham (received normal saline) and three experimental groups received TB with 75, 150 and 300 mg/kg doses via intraperitoneal injection for 14 days. Samples from all groups were collected at the end of the 14th day directly from the heart to evaluate thyroid hormone. The data were statistically analyzed in SPSS v. 12.
Ethical Considerations: This study was approved by the Research Ethics Committee of Ardabil University of Medical Sciences (code: IR.ARUMS.REC.1396.48).
Results: The results of this study showed that the T3 and T4 levels in the experimental groups 2 (150 mg/kg) and 3 (300 mg/kg) increased significantly compared to the control group (P<0.001 and P<0.01, respectively). The Thyroid Stimulating Hormone (TSH) level in the experimental groups 1 (75 mg/kg), 2 (150 mg/kg) and 3 (300 mg/kg) decreased significantly compared to the control group (P<0.05, P<0.001, P<0.001, respectively). 
Conclusion: Hydroalcoholic extract of TB can increase the serum levels of thyroid hormones and reduce TSH level.
Full-Text [PDF 2084 kb]   (441 Downloads) |   |   Full-Text (HTML)  (568 Views)  
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2019/05/17 | Accepted: 2019/10/7

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb