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Parastesh M, Nadi Z. The Effects of Regular Resistance Training on the Liver’s Inflammatory Indexes, Chemerin, Resistin, and Insulin Resistance Index in Healthy and Type 2 Diabetic Male Rats. J Arak Uni Med Sci 2020; 23 (1) :48-59
URL: http://jams.arakmu.ac.ir/article-1-6122-en.html

Background and Aim: The present study aimed to investigate the effect of a 10-week resistance training on the serum levels of insulin resistance index (HOMA-IR), the serum levels of liver enzymes, chemerin, and resistin in healthy and type 2 diabetic rats.
Methods & Materials: In this experimental study, 40 Wistar rats with the mean±SD weight of  200±48 gr were randomly divided into 4 groups (normal control, diabetic control, diabetic resistance training, and resistance training). The training groups performed regular resistance exercises for 10 weeks by ladders. Twenty-four hours after the last training session, the blood sample of rats was collected for resistin, chemerin, insulin, and liver enzymes. The obtained data were analyzed using one-way Analysis of Variance (ANOVA), Tukey posthoc test, Analysis of Covariance (ANCOVA), and Bonferroni posthoc test at a significance level of 0.05.
Ethical Considerations: This study was approved by the Research Ethics Committee of Arak University of Medical Sciences, Iran (Code: IR.ARAKMU.REC.1394.329).
Results: Diabetes induction significantly HOMA-IR, the serum levels of liver enzymes, resistin, and chemerin in the diabetic control group, compared to the healthy control group (P<‏0.05). Resistance training also significantly decreased insulin HOMA-IR, the serum levels of liver enzymes, resistin, and chemerin in the diabetic resistance training group, compared to the diabetic control group (P<0.05).
Conclusion: The obtained data suggested that resistance training improved liver enzymes in type 2 diabetic rats by decreasing the insulin HOMA-IR, the serum levels of chamirin, and resistin.