Volume 3, Issue 1 (Spring 2000)
J Arak Uni Med Sci 2000, 3(1): 6-10 |
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Pazouki S. The Effectiveness of Metolopramide Infusion on Postoperative Pain Control in Imam Khomeini Hospital. J Arak Uni Med Sci 2000; 3 (1) :6-10
URL: http://jams.arakmu.ac.ir/article-1-6605-en.html
URL: http://jams.arakmu.ac.ir/article-1-6605-en.html
School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract: (840 Views)
Through a clinical trail, the effects of metoclopramide infusion compared with a placebo in order to assess the effectiveness of the medicine in Imam Khomeini and Vali-Asr hospitals of Tehran were brought under consideration in two groups, which passessed the necessary condition. Metoclopramide was prescribed as a bolus dose of 0.5m/Kg and then its infusion as 1m/Kg at 6 hours intervals, while the control group were only received normal saline for the same duration. Sampling was simple and there was no distinctions between the groups. In review of the postoperative pain the patients were precisely looked after for the next 24 hours of the operation by the ward nurses and if it necessitated narcotics were prescribed. The analysis of the results manifested that the metoclopramide infusion doesn’t lessen the necessity of using narcotics significantly (P=0.174), but it can increase the analgesic effect of narcotics in case group compared with the control group. (P=0.0344) and the intervals of needing narcotics have been more (P=0.0223). In addition, the control group had considerably less incidence of nausea comparing with case group (P=0.0094) and the degree of vomiting was nearly less too (P=0.157). The sedation degree was significantly higher than the case group (P=0.033). No any other side effects of narcotics or metoclopramide, including itching, restlessness and tremor were observed. Metoclopramide infusion can increase the analgestic effects of narcotics. Drugs and significantly lessens the need for narcotics during the first hours of postoperation, Moreover it reduces the incidence problems arising from the site of incision and prescription of narcotics with high dose can be dangerous.
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