Volume 7, Issue 4 (Winter 2004)
J Arak Uni Med Sci 2004, 7(4): 33-38 |
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Farahani H, Naimi A R. Comparison of Glycosylated Hemoglobin and Oral Glucose Tolerance Test in Diagnosis of Diabetes in Person With Impaired Fasting Glucose. J Arak Uni Med Sci 2004; 7 (4) :33-38
URL: http://jams.arakmu.ac.ir/article-1-6812-en.html
URL: http://jams.arakmu.ac.ir/article-1-6812-en.html
Abstract: (812 Views)
Introduction: Glycosylated hemoglobin gives an average plasma glucose level over the past two to three months period. Diabetes is one of the most important causes of mortality and morbidity in the old ages, that usually due to its slow progress, patients do not pay attention to the disease. Early diagnosis can decrease many complications. This investigation is carried out with the aim of comparison results of FBs, GTT and HbA1c especially in persons with impaired dfasting glucose.
Materials and Methods: Our study is a cross sectional analytical study. 81 persons, 40 to 65 years old, without any history of diabetes, with FBs 103 to 140 mg/dl were selected according to convenience sampling method. FBS, GTT and HbA1c tests were done for all samples. Sensitivity, specially, positive predict value and negative predict value of tests were determined.
Results: In this study comparison of HbA1c with FBS showed 100% sensitivity and 12.5% specificity with positive predict value of 82% and negative predict value of 62.7%. In comparison of HbA1c with GTT, we observed 100% sensitivity and 63% specificity with positive oredict value of 6.3% and negative predict value of 100%. In other part of this investigation in comparison of FBS with GTT, 9.7% sensitivity and 100% specificity and positive predict value of 100% and negative predict value of 18.8% was reported.
Conclusion: According to results of the present study, due to very high sensitivity and significant positive predict value of HbA1c as compared to FBS, HbA1c measurement seems to be a good test in screening and diagnosis of diabetes.
Therefore, in impaired fasting glucose, we recommend measurement of both HbA1c and FBS. Also HbA1c can be used as a good replacement test for GTT in person with impaired fasting glucose.
Materials and Methods: Our study is a cross sectional analytical study. 81 persons, 40 to 65 years old, without any history of diabetes, with FBs 103 to 140 mg/dl were selected according to convenience sampling method. FBS, GTT and HbA1c tests were done for all samples. Sensitivity, specially, positive predict value and negative predict value of tests were determined.
Results: In this study comparison of HbA1c with FBS showed 100% sensitivity and 12.5% specificity with positive predict value of 82% and negative predict value of 62.7%. In comparison of HbA1c with GTT, we observed 100% sensitivity and 63% specificity with positive oredict value of 6.3% and negative predict value of 100%. In other part of this investigation in comparison of FBS with GTT, 9.7% sensitivity and 100% specificity and positive predict value of 100% and negative predict value of 18.8% was reported.
Conclusion: According to results of the present study, due to very high sensitivity and significant positive predict value of HbA1c as compared to FBS, HbA1c measurement seems to be a good test in screening and diagnosis of diabetes.
Therefore, in impaired fasting glucose, we recommend measurement of both HbA1c and FBS. Also HbA1c can be used as a good replacement test for GTT in person with impaired fasting glucose.
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Received: 2021/01/29 | Accepted: 2004/12/30
Received: 2021/01/29 | Accepted: 2004/12/30
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