Volume 25, Issue 5 (December & January 2022)                   J Arak Uni Med Sci 2022, 25(5): 49-60 | Back to browse issues page


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1- Student Research Committee, Arak University of Medical Sciences, Arak, Iran
2- Department of Clinical Biochemistry, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran , Dr.ZSalemi@arakmu.ac.ir
3- Department of Internal Medicine, Faculty of Medicine, Amirul Mominin Hospital, Arak University of Medical Sciences, Arak, Iran
4- Assistant Professor, Department of Social Medicine and Prevention, Arak University of Medical Sciences, Arak, Iran
Abstract:   (229 Views)
Introduction: Fetuin-A is a secreted protein from the liver, which plays a role in microvascular disorders of diabetes through insulin resistance and inflammation. The aim of this study is to investigate the amount of fetuin-A in diabetic patients without and with microvascular disorders.
Methods: 90 people in 4 groups, diabetic control, nephropathy, retinopathy and retinopathy-nephropathy participated in this research. Data were analyzed using Kruskal-Wallis and Pearson correlation tests. Measurement of parameters including VEGF, interleukin 8 (IL-8), insulin, interleukin 6 (IL- 6) and Fatuin-A was done by ELISA method. The concentration of C-reactive protein (CRP) was measured by nephrometric method.
Ethical considerations: This study was conducted after the approval of the protocol in the research ethics committee and receiving the ethical code number IR.ARAKMU.REC.1400.250 and according to the Declaration of Helsinki.
Results: The obtained results showed that the correlation between fetuin-A and VEGF in the control group was not significant (p=0.234), in the nephropathy group it was significant (p<0.01), in the retinopathy group it was significant (p<0.01) and in the retinopathy group - Nephropathy was significant (p=0.032). Also, the correlation between fetuin-A and interleukin-6 in the nephropathy group is not significant (p=0.285), in the retinopathy group is not significant (p<.075), in the retinopathy group is not significant (p<0.059) and in the retinopathy-nephropathy group. It was insignificant (p=0.113). The correlation between fetuin-A interleukin 8 in the control group is not significant (p=0.592), in the nephropathy group (p=0.592), in the retinopathy group (p=0.314) and in the retinopathy-nephropathy group (p= 0.362). The correlation between Fetuin-A and the homeostatic model of insulin resistance was significant in all groups (p<0.01). Fetuin-A and VEGF levels in the three groups of nephropathy and retinopathy increased significantly compared to the control group. The amount of interleukin 6, interleukin 8 and homeostatic model of insulin resistance in nephropathy, retinopathy and retinopathy-nephropathy groups has increased significantly compared to the control group.
Conclusions: Because fetuin-A is directly related to insulin resistance and VEGF production, its control can have an effect in preventing and controlling the development of microvascular disorders, especially in the early stages of diabetes. Although the results showed that fetuin-A level has no significant relationship with inflammatory factors such as interleukin 6 and interleukin 8, especially in the retinopathy-nephropathy group, but a significant increase of interleukin 6, interleukin 8 and CRP in patients with microvascular disorders to the diabetic control group, it shows the importance of inflammation in the development and progression of microvascular disorders and the importance of its control in diabetic patients.
 
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2023/01/8 | Accepted: 2023/09/21

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