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Background: Physalis Alkekengi is a perennial plant with a creeping and ryzumy stem belonging to the solanaceae family. This study investigates the possible effects of Physalis Alkekengi on plasma concentrations of some biochemical factors. Materials and Methods: Fifty male Wistar rats weighing an average of 190 ± 5 g were divided into five groups of ten: Control group without receiving any substances, control group with 2.0 ml/dl administration of the solvent, and three experimental groups receiving 0.4 (maximum), 0.2 (medium), and 0.1 (minimum) g/kg intra-peritoneal (IP) injections of the drug. The intra-peritoneal (IP) injection of the drug was done for 14 days and after this period, for conducting lab tests, blood sampling was done and the results were analyzed through ANOVA and Tukey test. Results: According to the results, protein and albumin plasma concentrations showed a significant increase (P<0.05) while creatinine plasma concentration, bilirubin, and urea nitrogen (BUN) did not reveal any significant changes. Conclusion: This family of plants contains significant amounts of glucocorticoids, such compounds are likely to increase liver and plasma proteins. In addition, due to the presence of compounds, such as physaline, vitamin C, and albumin, this extract is likely to increase blood pressure and, eventually, increase glomerulic refinement and diuretic properties therefore, the absence of significant increases in plasma concentrations of the substances produced by metabolism in plasma seems reasonable

Keywords: Bilirubin, Blood urea, Creatinine, Nitrogen, Physalis Alkekengi, Rats

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