TY - JOUR T1 - Evaluating the Role of Omega 3 on the Side Effects of Isotretinoin in Patients with the Acnea Vulgaris TT - بررسی اثر امگا 3 خوراکی بر عوارض جلدی مخاطی ایزوترتینوئین در بیماران مبتلا به آکنه ولگاریس JF - HBI_Journals JO - HBI_Journals VL - 19 IS - 10 UR - http://jams.arakmu.ac.ir/article-1-4503-en.html Y1 - 2017 SP - 81 EP - 87 KW - Acne vulgaris KW - Isotretinoin KW - Omega 3 N2 - BACKGROUND: Acne vulgaris is chronic inflamatory disease of the pilosebaceous unit.Patients experience psychological burdens like depression ,anxiety , and low self-esteem. Isotretinoin is used in the treatment of severe ,recalcitrant acne ;however,treatment commonly results in associated with a number of adverse effects that treatment stopped consequent this side effects. The aim of this study is to evaluate the effect of oral omega 3 on side-effects of isotretinoin . METHODS:One hundred eighteen patients with sever acne vulgaris were randomized to two groups. Control group recived isotretinoin (0.5 mg∕kg) alone and case group received isotretinoin (0.5 mg∕kg) combined with omega 3 (2 capsuls) daily.the treatment duration was 16 weeks.Mucocutaneous side-effects were assessed(4,8,12,16th wk). RESULTS:Lip dryness (4,8,12th wk) and dryness of nose, skin ,eye in the 4 th week in the patients treated with isotretinoin and omega3 was lesser than in the patients treated with isotretinoin (P value < 0.001). CONCLUSION:Omega 3 decreased the mucocutaneous side effects in the patients with acne vulgaris who received isotretinoin. M3 ER -