RT - Journal Article T1 - Effects of Alpha-Lipoic Acid Supplementation on Blood Pressure and Some Inflammatory Factors in Women with Rheumatoid Arthritis JF - HBI_Journals YR - 2015 JO - HBI_Journals VO - 17 IS - 12 UR - http://jams.arakmu.ac.ir/article-1-3186-en.html SP - 9 EP - 18 K1 - Alpha-lipoic acid K1 - Blood pressure K1 - Inflammation K1 - Rheumatoid arthritis AB - Background: Rheumatoid arthritis is an inflammatory disease. Hypertension could occur as a result of chronic inflammation in RA patients. Some evidence demonstrates anti-inflammatory effects of alpha-lipoic acid in inflammatory diseases. However, a limited number of studies have evaluated the effects of alpha-lipoic acid in rheumatoid arthritis. Therefore, the current study was designed to investigate the effects of alpha-lipoic acid supplementation on blood pressure and some inflammatory factors. Materials and Methods: The present study was a randomized, double-blinded, placebo-controlled clinical trial in which 70 female patients aged 20–50 years were randomized to two groups to receive either alpha-lipoic acid (1200 mg/day) or placebo. The intervention duration was 8 weeks. Systolic and diastolic blood pressures were measured before and after the supplementation period. Also, C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Statistical analysis was done using SPSS13 software. Results: 65 RA patients completed the trial. Systolic and diastolic blood pressure in alpha-lipoic acid group was significantly decreased in comparison with placebo group (p LA eng UL http://jams.arakmu.ac.ir/article-1-3186-en.html M3 ER -