%0 Journal Article %A Kazemi, Fahimeh %A Zahedi Asl, Saleh %T The Correlation of Plasma Levels of Apelin-13 with Insulin Resistance Index and Plasma Leptin of Diabetic Male Rats after 8-Week Aerobic Exercise %J Journal of Arak University of Medical Sciences %V 18 %N 6 %U http://jams.arakmu.ac.ir/article-1-3529-en.html %R %D 2015 %K Adipokine, Apelin-13, Exercise, Type 2 diabetes, %X Background: The physiological role of apelin, an adipokine secreted by adipose tissue , in insulin resistance and type 2 diabetes has been identified . The aim of this study was to determine t he correlation of plasma level s of apelin-13 with insulin resistance index (HOMA-IR) and plasma leptin of diabetic male rats after 8-week aerobic exercise . Materials and Methods: Peresent study was an experimental study with animal model. Twenty eight diabetic male Wistar rats were divided into 3 groups: Non-diabetic (n=9), control diabetic (n=9) and trained diabetic (n=10). Type 2 diabetes was induced by intraperitoneal injection of nicotinamide and streptozotocin. The trained diabetic rat ran 8-week on treadmill progressively. After the training period, plasma levels of glucose, insulin, leptin and apelin-13 were measured and HOMA-IR was calculated. One-way analysis of variance (ANOVA) and Pearson’s correlation were used for analyzing data. p<0.05 was considered to be statistically significant. Results: A significant decrease in plasma levels of glucose, insulin and leptin and HOMA-IR in trained diabetic vs control diabetic rats, a significant increase in plasma levels of apelin in trained diabetic vs non-diabetic and control diabetic rats and a significant negative correlation of plasma levels of apelin with HOMA-IR and plasma leptin in trained diabetic rats was observed. Conclusion: In present study, 8-week aerobic training by improvement of insulin sensitivity (decrease of HOMA-IR and plasma leptin) increased plasma levels of apelin-13 in diabetic male rats. %> http://jams.arakmu.ac.ir/article-1-3529-en.pdf %P 51-60 %& 51 %! %9 Original Atricle %L A-10-3399-1 %+ Department of Physical Education and Sport Sciences, Shahid Beheshti University, Tehran, Iran %G eng %@ 1735-5338 %[ 2015