TY - JOUR JF - HBI_Journals JO - J Arak Uni Med Sci VL - 20 IS - 5 PY - 2017 Y1 - 2017/8/01 TI - Evaluation of Serum Biochemical and Histopathological Changes in Mice-Diabetic Kidney Followed by Simultaneous Injection of Nanoparticles of Zinc oxide and Thiamine TT - بررسی تغییرات بیوشیمیایی سرم و هیستوپاتولوژیک کلیه در موش‌های دیابتی شده به دنبال تزریق همزمان نانوذرات اکسید روی و تیامین N2 - Abstract Background: In this study, the effects of zinc oxide nanoparticles (ZnO NPs) and thiamine on the blood biochemical markers and kidney histopathological changes after experimental diabetes in mice was investigated. Materials and Methods: For this purpose, 56 mice were randomly divided into 8 groups of 7 each. Two groups of animals as controls (A) and thiamine (G) were considered. Other groups were diabetic by alloxan at a dose of 180 mg/kg. Group B mice were considered as diabetic group. To diabetic mice into Group C and D , ZnO NPs in concentrations of 0.1 and 0.5 mg/kg were intraperitoneally injected. Groups E and F; to these groups of diabetic mice, ZnO NPs in concentration of 0.1 and 0.5 mg/kg along with thiamin (30 mg/l) was injected. ZnO NPs in concentration of 0.1 was injected to group H mice. Changes in renal tissue along with some biochemical parameters were measured. Results: The results showed that diabetes induced changes in some of the serum biochemical factors (GGT, BUN and creatinine) in rats (p<0.05). However, the administration of nanoparticles and thiamine reduced these negative effects. Exposure to diabetes causes changes in the kidney tissue of the mouse, in the disturbance of scaffolds for tissue integrity clutter, fragmentation of some convoluted tubules and congestion within the connective tissue. Conclusion: Treatment of the diabetes mice by ZnO NPs and thiamine improves renal histopathologic structure and blood biochemistry levels. SP - 103 EP - 118 AU - Khaje Gandomani, Ahmad AU - Fatahian Dehkordi, Rahmat Allah AU - Heidarnejad, Mohamad Saeed AU - Jafarian Dehkordi, Mohsen AD - Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran KW - Diabetes KW - Kidney KW - Mouse KW - Thiamine KW - Zinc oxide nanoparticles UR - http://jams.arakmu.ac.ir/article-1-5070-en.html ER -