AU - Shojapuor, Mana AU - Mosayebi, Ghasem AU - Ghasami, Keyvan AU - Ghazavi, Ali AU - Sadeghi, Abdolrahim TI - Vitamin D receptor gene polymorphism in patients with multiple sclerosis in Mar kazi Province PT - JOURNAL ARTICLE TA - HBI_Journals JN - HBI_Journals VO - 15 VI - 4 IP - 4 4099 - http://jams.arakmu.ac.ir/article-1-1287-en.html 4100 - http://jams.arakmu.ac.ir/article-1-1287-en.pdf SO - HBI_Journals 4 ABĀ  - Background: Multiple sclerosis (MS) is an autoimmune disease which demyelinates the central nervous system. Vitamin D, is a potential environmental factor which influences this disease. The majority of the biological activities of the polymorphism forms of vitamin D are done through its receptor gene (VDRG). The aim of this study was to examine the relationship between BsmI polymorphisms in VDRG and the incidence of MS. Materials and Methods: In this case-control study, the BsmI polymorphism in the VDRG was studied in 80 Iranian MS patients and 50 healthy controls of the same genetic background and age through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method Results: There was a significant difference in the frequency of BsmI VDRG polymorphism genotypes between MS patients and controls (P=0.023). Conclusion: This study indicated that the VDRG BsmI polymorphism is associated with MS in this population. CP - IRAN IN - LG - eng PB - HBI_Journals PG - 34 PT - YR - 2012