TY - JOUR T1 - Study the Association Between CPEB2 Gene Polymorphism with the Risk of Idiopathic Azoospermia/Severe Oligozoospermia of Men TT - بررسی ارتباط بین چندشکلی ژن CPEB2 با خطر ابتلای مردان به آزواسپرمی/الیگواسپرمی شدید ایدیوپاتیک JF - HBI_Journals JO - HBI_Journals VL - 21 IS - 6 UR - http://jams.arakmu.ac.ir/article-1-5692-en.html Y1 - 2018 SP - 88 EP - 98 KW - Azoospermia KW - CEBP2 gene KW - Oligozoospermia KW - Rs12643066 polymorphism N2 - Background and Aim: The CPEB gene encodes an important protein, which play critical roles in translational regulation of oogenesis and spermatogenesis procedures. The aim of this study was to evaluate the association between CPEB2 rs12643066 gene polymorphism with the risk of idiopathic azoospermia/severe oligozoospermia of men. Materials and Methods: This study was designed as a case-control investigation on 100 blood samples of men with idiopathic azoospermia/severe oligozoospermia and 100 blood samples of fertile men. To evaluate CPEB2 gene polymorphism, PCR-RFLP method was used. Data analysis was performed by chi-squat test. Findings: In the present study, the genotype frequencies did not show a statically significant difference between groups (p=0.479, OR=1.222; CI=0.701-2.129). Conclusion: The study showed that the CPEB2 gene polymorphism was not associated with the risk of idiopathic azoospermia/severe oligozoospermia of men. However, it is conceivable that evaluation of this gene polymorphism can not be used as a biomarker in diagnosis of men with idiopathic azoospermia/severe oligozoospermia. M3 ER -