TY - JOUR T1 - Study of the extracellular trans zinc effect on passive avoidance learning in male Wistar rats TT - بررسی اثر روی خارج سلولی ترانس وکانال های کلسیمی وابسته به ولتاژ بریادگیری شرطی احترازی غیرفعال در موش های صحرایی نر نژاد ویستار JF - HBI_Journals JO - HBI_Journals VL - 11 IS - 1 UR - http://jams.arakmu.ac.ir/article-1-191-en.html Y1 - 2008 SP - 88 EP - 96 KW - Avoidance learning KW - passive KW - zinc KW - extracellular KW - trans KW - calcium channel KW - antagonist N2 - Introduction: In this study the effect of extracellular trans zinc and voltage sensitive calcium channels on different aspects of learning and memory has been investigated. Materials and Methods: This is an experimental study in which the effect of a calcium channel antagonist (Verapamil) and zinc chelator (Ca-EDTA), on passive avoidance learning (shuttle box apparatus) has been examined by intraperitoneal administration of defferent doses of these drugs. Data was analyzed using one way analysis of variance. Results: Result of intraperitoneal injection of 100 milimolar Ca-EDTA indicated that it has no effect on the acquisition, consolidation, and retrieval of passive avoidance learning. Verapamil (100 and 150 micrograms) as a L-type voltage gated calcium channel antagonist, decreased acquisition and consolidation but not retrieval of passive avoidance behaviour. These effects were dose dependent. The simltaneous effect of Ca-EDTA and verapamil was also studied. Ca-EDTA (100milimolar) and verapamil (100 micrograms) have negative effects on consolidation of passive avoidance learning. Conclusion: Probably, common mechanisms are involved in acquisition and consolidation of passive avoidance learning, and zinc and calium ions play interactive roles in this aspect. M3 ER -