%0 Journal Article %A Dorostkar, Hamid Reza %A Ansari Hadipour, Hadi %A Goodarzi, Mohammad Taghi %T Relationship Between Structural Changes of Hemoglobin with Oxidative Status of Plasma in Diabetic Hemodialysis Patients %J Journal of Arak University of Medical Sciences %V 17 %N 7 %U http://jams.arakmu.ac.ir/article-1-2709-en.html %R %D 2014 %K Diabetic hemodialysis patient, Erythrocyte, Hemoglobin, Oxidative status, %X Background: There is a relationship between diabetes, dialysis and oxidative stress. The aim of this study was the comparison of structural changes in Hb, oxidative damages in plasma proteins, and antioxidant capacity in diabetic hemodialysis patients with those of control subjects. Materials and Methods: In this experimental study, blood samples obtained from diabetic hemodialysis patients and control group. Oxidative damages in plasma proteins were determined by carbonyl assay and antioxidant power of plasma was performed by FRAP assay. Conformational changes in Hb were detected by spectrophotometric analysis. Blood glucose, urea, creatinine and uric acid in patients were determined usnig routine laboratory methods. Statistical analysis were performed by using regression analysis and t-test in SPSS20 software. Results: This study showed a significant correlation between carbonyl content of plasma proteins and optical density of Hb at 630 and 275 nm which corresponds to structural changes in Hb. ferric reducing ability of plasma (FRAP), as an index of total antioxidant capacity of plasma was found to be enhanced significantly in diabetic patients receiving hemodialysis (from 1019.62±129 to 1354.54±129 molare, p %> http://jams.arakmu.ac.ir/article-1-2709-en.pdf %P 59-70 %& 59 %! %9 Original Atricle %L A-10-715-4 %+ Department of Biochemistry and Genetics, Arak University of Medical Sciences, Arak, Iran %G eng %@ 1735-5338 %[ 2014