RT - Journal Article T1 - The effect of Lactobacillus brevis on cutaneous wound healing in rats on days 7 and 21 JF - HBI_Journals YR - 2011 JO - HBI_Journals VO - 14 IS - 4 UR - http://jams.arakmu.ac.ir/article-1-720-en.html SP - 30 EP - 37 K1 - Cutaneous Wound K1 - Exopolysaccharid K1 - Healing K1 - Lactobacillus brevis K1 - Probiotic AB - Background: Today, there is growing interest in using traditional medicine for healing cutaneous wounds. Probiotics are defined as different microorganisms that may have positive effects on prevention or treatment of special pathologic conditions. The present study was designed to investigate the effect of Lactobacillus brevis on cutaneous wound healing. Material and Methods: In this experimental study, through phenol-sulfuric acid method, 22 strains of lactobacillus isolated from dairy-traditional products were investigated in terms of exopolysaccharide production. Lactobacillus brevis, which had high exopolysaccharide (EPS) production, was selected. A wound was created on the back of male Wistar rats in control, negative control, and experimental groups. Control and experimental groups underwent regional treatment by eucerin and eucerin contained Lactobacillus brevis, respectively, but the negative-control group did not receive any treatment. On days 1, 7 and 21, the rats were killed and their cutaneous wound samples were studied. Data analysis was done through SPSS version 11.5. Results: The percentage of wound healing (99.53%) and inflammation in the experimental group on day 21 compared to control (90.55%) and negative groups (91.14%) was significantly higher (P LA eng UL http://jams.arakmu.ac.ir/article-1-720-en.html M3 ER -