Journal of Arak University of Medical Sciences
مجله دانشگاه علوم پزشكي اراك
J Arak Uni Med Sci
Medical Sciences
http://jams.arakmu.ac.ir
46
journal46
1735-5338
2008-644X
fa
jalali
1396
5
1
gregorian
2017
8
1
20
5
online
1
fulltext
fa
بررسی ارتباط بین هسته PAG چپ و راست در آزمون فرمالین در موش صحرایی در درد یکطرفه
The Relationship Between Left and Right PAG in Rat in Unilateral Pain in the Formalin Test
علوم پایه
Basic Sciences
پژوهشي اصیل
Original Atricle
<p dir="RTL" style="margin-top:0cm;margin-right:28.9pt;margin-bottom:0cm;margin-left:28.9pt;margin-bottom:.0001pt;text-align:justify;line-height:normal;direction:rtl;unicode-bidi:embed;"><strong><span style="font-family:b mitra;">چکیده</span></strong></p>
<p dir="RTL" style="margin-top:0cm;margin-right:28.9pt;margin-bottom:0cm;margin-left:28.9pt;margin-bottom:.0001pt;text-align:justify;line-height:normal;direction:rtl;unicode-bidi:embed;"><strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;">زمینه و هدف</span></span></strong><strong><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">:</span></span></span></strong> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">درد از فرآیندهای حفاظتی بدن میباشد</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;"> .</span></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;">در سیستم عصبی مرکزی مسیرهای متفاوتی برای کنترل درد وجود دارد. یکی از این مسیرها سیستم نزولی کنترل درد میباشد. هسته خاکستری دور قناتی </span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">PAG</span></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"> از ساختارهای شناخته شده میباشد که در انتقال و تعدیل درد نقش مهمی را ایفاء میکند. هدف از این تحقیق، بررسی درصد رابطه بین ناحیه راست و چپ هسته </span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">PAG</span></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"> در ایجاد درد یک طرفه در پای چپ می</span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;">باشد.</span></span></p>
<p dir="RTL" style="margin-top:0cm;margin-right:28.9pt;margin-bottom:0cm;margin-left:28.9pt;margin-bottom:.0001pt;text-align:justify;line-height:normal;direction:rtl;unicode-bidi:embed;"><strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;">مواد و روش</span></span></strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;"></span></span><strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;">ها</span></span></strong><strong><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">:</span></span></span></strong> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در این تحقیق از 60 موش صحرایی نر (30+280 گرم) نژاد ویستار در شش گروه (3 گروه آزمایش و 3 گروه کنترل) استفاده گردید. در گروههای آزمایش، داروی و بیحسی لیدوکائین به میزان 5/0 میکرولیتر در هسته چپ </span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">PAG</span></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;">، در هسته سمت راست </span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">PAG</span></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"> و در هر دو هسته چپ و راست تزریق گردید و در گروههای کنترل سرم فیزیولوژی در نواحی مذکور تزریق گردید. پس از 15 دقیقه، 50 میکرولیتر از فرمالین 5/2 درصد به صورت زیر جلدی در پای چپ حیوان تزریق شد و میزان درد در فواصل 15 ثانیهای تا مدت زمان یک ساعت ثبت گردید. </span></span></p>
<p dir="RTL" style="margin-top:0cm;margin-right:28.9pt;margin-bottom:0cm;margin-left:28.9pt;margin-bottom:.0001pt;text-align:justify;line-height:normal;direction:rtl;unicode-bidi:embed;"><strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;">یافتهها:</span></span></strong> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">نتایج</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">نشان</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">داد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">که</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">صورت</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">ایجاد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">درد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">سمت چپ بدن</span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"> موش</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">صحرایی،</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">علاوه بر ناحیه سمت چپ </span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;">هسته </span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">PAG</span></span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">طرف مقابل آن</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">نیز</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">به</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">درد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">واکنش نشان</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">می</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">دهد</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">.</span></span></span></p>
<p dir="RTL" style="margin-top:0cm;margin-right:28.9pt;margin-bottom:0cm;margin-left:28.9pt;margin-bottom:.0001pt;text-align:justify;line-height:normal;direction:rtl;unicode-bidi:embed;"><strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;">نتیجه</span></span></strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;"></span></span><strong><span style="font-family:b mitra;"><span style="font-size:12.0pt;">گیری</span></span></strong>: <span style="font-family:b mitra;"><span style="font-size:12.0pt;">این</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">مطالعه</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">نشان</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">داد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">که</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در آزمون فرمالین،</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">هر دو</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">ناحیه چپ و راست</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">هسته </span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">PAG</span></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"> به طور</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">معنی</span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;">داری</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">درد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">ایجاد</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">شده</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">یک</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">طرف</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">بدن</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">در</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">موش</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">صحرایی</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">نقش دارند</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">که</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">هسته طرف مقابل اثر</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">کم</span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;"></span></span><span style="font-family:b mitra;"><span style="font-size:12.0pt;">تری</span></span> <span style="font-family:b mitra;"><span style="font-size:12.0pt;">دارد</span></span><span dir="LTR"><span style="font-family:times new roman,serif;"><span style="font-size:12.0pt;">.</span></span></span></p>
<p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family: times new roman;"><strong>Abstract</strong></span></span></p>
<p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family: times new roman;"><strong><em>Background:</em></strong> Pain is a protective process in the body. There are different pathways for pain control in the central nervous system. Descending pain control system is one of pathways. The periaqueductal gray (PAG) is a structure known for its role in pain transmission and modulation. The aim of this study is to investigate the percent of interaction between the left and right PAG in unilateral left foot induced pain<span dir="RTL">.</span></span></span></p>
<p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family: times new roman;"><strong><em>Materials and Methods:</em></strong> In this study, 60 rats (280+30g) in six groups were used (3test groups and 3 controls groups). In test groups, 0.5 microliter lidocaine was injected in the left PAG, right PAG or both to make local anesthesia. In control groups, 0.5 microliter of normal saline were injected. After 15 minutes, 50 microliter of 2.5% of formalin were injected subcutaneously to right hind paw of rats and nociception was detected in every 15 seconds for one hour<span dir="RTL">. </span></span></span></p>
<p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family: times new roman;"><strong><em>Results:</em></strong> The induction of unilateral pain (left hind paw) in rats, can affect not only the ipsilateral but also the contralateral PAG nucleus<span dir="RTL">.</span></span></span></p>
<p style="text-align: justify;"><span style="font-size:14px;"><span style="font-family: times new roman;"><strong><em>Conclusion:</em></strong> This study showed that the left and right PAG nuclei have significant role on unidirectional nociception in formalin test in rats. The contralateral PAG, however, has a minor effect on nociception<span dir="RTL">.</span></span></span></p>
آزمون فرمالین, PAG, درد, لیدوکائین
Formalin test, Lidocaine, PAG, Pain
57
70
http://jams.arakmu.ac.ir/browse.php?a_code=A-10-4902-1&slc_lang=fa&sid=1
Olya
Moshiri
علیا
مشیری
rahimi.2011k@yahoo.com
4600319475328460055821
4600319475328460055821
No
Department of Basic Sciences, Shiraz University, Shiraz, Iran
گروه علوم پایه، دانشگاه شیراز، شیراز، ایران
Javad
Sajedianfard
جواد
ساجدیان فرد
sajedian@shirazu.ac.ir
4600319475328460055822
4600319475328460055822
Yes
Department of Basic Sciences, Shiraz University, Shiraz, Iran
گروه علوم پایه، دانشگاه شیراز، شیراز، ایران
Mina
Gheisari
مینا
قیصری
ghaisari@yahoo.com
4600319475328460055823
4600319475328460055823
No
Department of Basic Sciences, Shiraz University, Shiraz, Iran
گروه علوم پایه، دانشگاه شیراز، شیراز، ایران