Journal of Arak University of Medical Sciences
مجله دانشگاه علوم پزشكي اراك
J Arak Uni Med Sci
Medical Sciences
http://jams.arakmu.ac.ir
46
journal46
1735-5338
2008-644X
10.66224/jams
fa
jalali
1405
2
1
gregorian
2026
5
1
29
2
online
1
fulltext
fa
تأثیر استروئید ترنبولون و پپتید CJC طی دو ماه تمرینات مقاومتی بر آسیب‌های کبدی رت‌های نر بالغ: یک مطالعه تجربی
Effect of Trenbolone Steroid and CJC Peptide During Two Months of Resistance Training on Liver Damage in Adult Male Rats: An Experimental Study
عمومى
General
پژوهشي اصیل
Original Atricle
<span style="font-size:11pt"><span style="line-height:101%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:101%"><span b="" nazanin="" style="font-family:"><span style="color:black">مقدمه:</span></span></span></span></b> <span lang="FA" style="font-size:9.0pt"><span style="line-height:101%"><span b="" nazanin="" style="font-family:"><span style="color:black">مصرف استروئیدها و سایر مکمل‌ها ممکن است بر بافت‌های بدن از جمله کبد تأثیر داشته باشد، پژوهش حاضر با هدف بررسی تأثیر استروئید ترنبولون و پپتید </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:101%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CJC</span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:101%"><span b="" nazanin="" style="font-family:"><span style="color:black"> طی دو ماه تمرینات مقاومتی بر آسیب‌های کبدی رت‌های نر بالغ انجام شد</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:101%"><span b="" nazanin="" style="font-family:"><span style="color:black">. </span></span></span></span><span lang="FA" style="line-height:101%"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:104%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black">روش کار:</span></span></span></span></b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> 40 رت نر ویستار (سن 8 هفته و وزن </span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black">۱۸۰</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> تا </span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black">۲۲۰</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> گرم) به طور تصادفی در 4 گروه 10تایی کنترل، تمرین-ترنبولون، تمرین-</span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:104%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CJC</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و تمرین قرار گرفتند. تمرین مقاومتی به مدت هشت هفته و هفته‌ای سه جلسه انجام شد و هم‌زمان با تمرین، تزریقات مورد نظر نیز برای گروه‌های ترنبولون و </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:104%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CJC</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> به‌صورت یک بار در هفته از طریق عضلات سرینی و پشت ران به مقدار 5 میکرو‌گرم به ازای هر کیلوگرم وزن بدن انجام شد. پس از اتمام دوره پروتکل پژوهشی، وزن، نسبت وزن کبد به وزن نمونه‌ها و آسیب کبدی با استفاده از میکروسکوپ نوری ارزیابی شد. از آزمون تحلیل واریانس یک طرفه و آزمون تعقیبی </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:104%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Tukey</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> در سطح 05/0 > </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:104%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:104%"><span b="" nazanin="" style="font-family:"><span style="color:black"> جهت تجزیه و تحلیل داده‌ها استفاده شد. </span></span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="line-height:104%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:102%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black">یافته‌ها:</span></span></span></span></b> <span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black">گروه‌های دریافت کننده ترنبولون و پپتید </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:102%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CJC</span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black"> افزایش معناداری در وزن نسبت به دیگر گروه‌ها نداشتند (0/05 </span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span majalla="" sakkal="" style="font-family:"><span style="color:black">≤</span></span></span></span> <span dir="LTR" style="font-size:9.0pt"><span style="line-height:102%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black">). اما نسبت وزن کبد به وزن بدن در گروه ترنبولون نسبت به گروه تمرین و کنترل معنی‌دار بود (0/05 > </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:102%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black">). پرخونی عروق، واکوئل‌های چربی، التهاب و دژنراسیون در کبد گروه‌های ترنبولون و پپتید </span></span></span></span><span dir="LTR" style="font-size:9.0pt"><span style="line-height:102%"><span new="" roman="" style="font-family:" times=""><span style="color:black">CJC</span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black"> به طور معنی‌داری نسبت به گروه کنترل و تمرین بیشتر بود (05/0 </span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span majalla="" sakkal="" style="font-family:"><span style="color:black">≥</span></span></span></span> <span dir="LTR" style="font-size:9.0pt"><span style="line-height:102%"><span new="" roman="" style="font-family:" times=""><span style="color:black">P</span></span></span></span><span lang="FA" style="font-size:9.0pt"><span style="line-height:102%"><span b="" nazanin="" style="font-family:"><span style="color:black">)..</span></span></span></span> <span dir="LTR" style="font-size:10.0pt"><span style="line-height:102%"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span></span></span></span><br>
<b><span dir="RTL" lang="AR-SA" style="font-size:9.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">نتیجه‌گیری:</span></span></span></span></span></b> <span dir="RTL" lang="FA" style="font-size:9.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">بر اساس یافته‌ها این پژوهش در نمونه‌هایی که این استروئیدهای آنابولیک را مصرف کرده بودند نشانه‌هایی از آسیب‌های کبدی یافت شد</span></span></span></span></span><span dir="RTL" lang="AR-SA" style="font-size:9.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"><span style="letter-spacing:-.1pt">.</span></span></span></span></span>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet="">Introduction:</span></span></b><span style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet=""> The use of steroids and other supplements may affect body tissues, including the liver. This study aimed to investigate the effect of trenbolone steroid and CJC peptide during two months of resistance training on liver damage in adult male rats.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet="">Methods:</span></span></b> <span lang="EN-GB" style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet="">40 male Wistar rats (aged 8 weeks and weighing 180–220 g) were randomly divided into four groups of 10: control, exercise-trenbolone, exercise-CJC, and exercise. Resistance training was performed for eight weeks, three sessions per week. Simultaneously with training, the specified injections were administered to the trenbolone and CJC groups once a week into the gluteal and posterior thigh muscles at a dose of µg/kg body weight. After the intervention, body weight, 5 liver weight-to-body weight ratio, and liver damage were assessed using light microscopy. One-way analysis of variance and Tukey's post hoc test at a significance level of P < 0.05 were used to analyze the data</span></span><span style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet="">.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet="">Results: </span></span></b><span lang="EN-GB" style="font-size:8.0pt"><span ms="" style="font-family:" trebuchet="">The groups receiving trenbolone and CJC peptide did not show a significant increase in body weight compared with the other groups P ≥ 0.05. However, the liver weight-to-body weight ratio in the trenbolone group was significantly different from that in the training and control groups. Vascular hyperemia, fatty vacuoles, inflammation, and degeneration in the liver of the trenbolone and CJC peptide groups were significantly more pronounced than in the control and exercise groups (P≤0.05).</span></span></span></span></span></span></span><br>
<b><span style="font-size:8.0pt"><span style="line-height:115%"><span ms="" style="font-family:" trebuchet=""><span style="letter-spacing:-.2pt">Conclusions:</span></span></span></span></b> <span lang="EN-GB" style="font-size:8.0pt"><span style="line-height:115%"><span ms="" style="font-family:" trebuchet=""><span style="letter-spacing:-.2pt">Based on the findings of this study, signs of liver damage were found in the rats that received these anabolic steroids</span></span></span></span>
ترنبولون؛
پپتید CJC؛
تمرین مقاومتی؛
آسیب کبدی
Trenbolone,
CJC peptide,
Resistance training,
Liver injury
99
106
http://jams.arakmu.ac.ir/browse.php?a_code=A-10-4715-5&slc_lang=fa&sid=1
Mehdi
Timouri
مهدی
تیموری
timouri@gmail.com