2024-03-28T14:27:19+03:30 http://jams.arakmu.ac.ir/browse.php?mag_id=11&slc_lang=fa&sid=1
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 The association of primary headaches with Multiple Sclerosis Alireza Rezayi Ashtiani r110_ashtiani@yahoo.com Fardin Faraji Mahdi Moghadasi Shadi Pirasteh Afsoun Talaie zanjani Introduction: Relationship between Multiple Sclerosis (MS) and primary headaches is not well recognized yet and the studies that have been done had different results. The aim of this study was to investigate the relation between primary headaches and multiple sclerosis. Materials and Methods: In this historical cohort study, 117 patients with actual MS were selected by convenience sampling as case group and 351 healthy subjects as control group. The incidence of primary headaches was assessed by a physician using a questannaire. Variables under investigation were age, sex, type of MS, Expanded Disability Status Score (EDSS), and characteristics of headache based on International Headache Society (IHS) classification. Data analysis was done using Chi-square, t-test, Fisher exact test, and logistic regression. Results: 53.8% of MS group and 27.4% of control group had chronic headaches (p=0.0001). Frequency of Migraine and tension type headaches among patients with headache in MS group were 73.1% and 26.98%, and in control group were 40.6% and 58.7% respectively. There was a statistically significant relation between Relapsing-Remitting MS and migraine headache (p<0.001).There was not any correlations between headache and using Interferone, MS duration, and EDSS. Conclusion: The results of this study indicate that primay headaches, especialy migraine without aura, are common in MS patients comparing to general population. Primary headache Migraine headache tension headache multiple sclerosis 2008 3 01 1 6 http://jams.arakmu.ac.ir/article-1-179-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 The effect of dietary Margarine oil on Wistar rat reproduction Mohammad reza Palizvan palizvan@yahoo.com Zahra Sary Mahmoud reza Nakhaee Introduction: Many research demonstrate the effect of margarine trans fatty acids on many physiological mechanisms in both human and animals. The purpose of this research was to evaluate the effects of margarine oil on reproduction in Wistar rat. Materials and Methods: ‏This is an experimental study in which 46 Wistar female and male rats were divided into 4 groups. Male and female rats in group 1 were fed by 3% Margarine oil and standard food, in group 2 only female rats and in group 3 only male rats had Margarine oil with the standard food. Male and female rats in group 4 (as control group) had only standard food. Administration was started one month pre mating and continued during mating, gestation and lactation periods. After delivery, the pups were assessed for overall number, sex ratio, body weight, and mortality. One way analysis of variance was used for data avalysis. Results: ‏Results showed that weight and female ratio of pups were significantly increased in group 2 as compared to group 1 and control. Also the comparison of pups’ mortality in the four groups showed that pups mortality was increased in group 2 as compared to the other groups. On the other hand there was no significant difference in number of pups in the four groups. Conclusion: The results showed that dietary Margarine oil administration to female rats can significantly increase weight, ratio of female pups and mortality of pups. Margarine trans fatty acid dietary fat rat reproduction 2008 3 01 7 14 http://jams.arakmu.ac.ir/article-1-180-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Effect of the administrated oxygen ratio during anesthesia on incidence of wound infection in clean-contaminated surgery Mohammadali Hesami mahessami@hotmail.com Amir reza Naimi Hamid reza Biranvand Introduction: Despite different methods implemented, surgical wound infection is still an important cause of mortality and morbidity of patients which impose a considerable cost on health care system. According to recent data, administration of supplemental oxygen during operation can reduce the risk of wound infection due to increased tissue oxygenation and therefore better elimination of bacteria by oxidative killing. This study is done to investigate the effect of administered oxygen ratio on the incidence of wound infection in clean-contaminated surgery. Materials and Methods: This is a double blind clinical trial. 584 patients from both sexes between 18 to 60 years old, who were condidated for clean-contaminated surgery were divided into two equal groups randomly. One recived 80% and the other 40% FIO2 during anesthesia. The frequency of wound infection between the two groups was assessed during a two weeks period. Results: Of patients receiving 80% FIO2, 11 (3.9%) patients, and the group recieving 40% FIO2, 25(8.1%) patients had wound infection (p<0.05). Conclusion: This study similar to previous studies showed the positive effect of supplemental oxygen in decreasing risk of surgical wound infection. Therefore according to the low risk and low cost and effectivness of this method in patients undergone surgery, it is recommended in clean-contaminated surgery. Surgery wound infection oxygen anesthesia 2008 3 01 15 20 http://jams.arakmu.ac.ir/article-1-181-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 The effect of pulsed ultrasound on serum Alkaline Phosphatase during bone healing of tibia in New Zealand rabbit Abolhasan Sakhaie anatomy_47@yahoo.com Ali Ghazavi Hoseinali Hadi Ghasem Mosayebi Introduction: Serum Alkaline Phosphatase (ALP) is a glycoprotein that is secreted from osteoblasts. In fractures, the rate of ALP will be changed. Low intensity pulsed ultrasound accelerates the growth and remodeling of fractures. However the relation between pulsed ultrasound and changing the rate of serum ALP in New Zeland rabbit is not studied yet. The aim of this study is to investigate the effect of pulsed ultrasound on serum ALP during bone healing of tibia in New Zealand rabbit. Materials and Methods: This is an experimental study. 54 male and mature New Zealand rabbits were randomly divided into six groups (3 experimentals and 3 controls). All of them were operated for inducing a model of experimental fracture. After repair of wounds, the right leg of experimental groups was exposed to pulsed ultrasound for 2, 4 and 6 weeks. The control groups were kept without any intervention during the same time. After experiment, the rabbits were anesthesied and blood samples were taken from their hearts for ALP serology, and then the rabbits were killed. Blood was centrifuged and serum ALP was read by spectrophotometer. Data was analyzed by Mann-Whitney U and Kruskal-Wallis tests. Results: Results showed that the mean serum ALP level in experimental group after 4 weeks exposing to pulsed ultrasound was significantly higher as compared to control group (p= 0.03). There was no significant difference between the other groups. Conclusion: The results of this study demonstrate that pulsed ultrasound wave increases serum ALP and accelerates the bone healing. Pulsed ultrasonography Alkaline Phosphatase (ALP) bone healing 2008 3 01 35 39 http://jams.arakmu.ac.ir/article-1-182-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 The comparison of topical nasal Mupirocin and single dose of oral Ciprofloxacin in treatment and reinfection of Staphylococcus Aureus carriers in personnel of Vali-e-asr hospital, Arak, 2004 Hosein Sarmadian hoss92001@yahoo.com Farshideh Didgar Hamid Abtahi Introduction: Staphylococcus Aureus is one of the most important pathogenes in human. Regarding the ability of this bacterium in nasal colonization, carriers can increase the incidence of many nosocomial infections. This study was designed to compare the efficacy of two antimicrobial regimens (topical nasal Mupirocin and oral Ciprofloxacin) in treatment of Staphylococcus Aureus carriers and its recurrence. Materials and Methods: This study is a triple blind clinical trial that was performed on 366 cases of Vali-e-asr hospital personnel. Nasal cultures were prepared from all these cases. Among them, 45 cases were carriers which were divided in two groups (A and B). Group A were treated by single dose of oral Ciprofloxacin (1500 mg) and Vit A+D ointment as placebo for 5 days (twice a day) and group B were treated by single dose of oral placebo and nasal Mupirocin ointmdent for 5 days (twice a day). After this period, nasal cultures were repeated in the two groups to evaluate the efficacy of treatment. Also after 5 weeks the last cultures were performed in order to determine the prevalence of reinfection. Results were analyzed using Chi-square test. Results: Results showed that, 12.9% of Vali-e-asr hospital personnels were nasal carriers of Staphylococcus Aureus. Also the efficacy of topical nasal Mupirocin regimen (89.5%) was significantly higher than single dose of oral Ciprofloxacin regimen (55%) (p=0.019). But there was no significant difference between prevalence of reinfection in topical (13.3%) and oral regiment (20%). Conclusion: According to the present data, it seems that topical Mupirocin therapy is more effective than single dose of oral Ciprofloxacin in treating Staphylococcus Aureus carriers. However there is no significant difference in the prevalence of reinfection between the two methods. Staphylococcus carrier Mupirocin Ciprofloxacin 2008 3 01 40 46 http://jams.arakmu.ac.ir/article-1-183-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Effects of oral Morphine on the development of olfactory bulb in rat embryo Saghar Saeedabadi Mehrangiz Sdoughi Hedayat Sahraei h.sahraei@bmsu.ac.ir Hosein Bahadoran Javad Fahanik babaiee Sirous Jalili Introduction: Opioids abuse is a nationwide problem in our country. Regarding the potential of these drugs in crossing placenta they can cause many defects in fetuses of human and also animals. In the present study, the effects of maternal Morphine consumption on olfactory bulb development in rats have been investigated. Materials and Methods: Female Wistar rats (weight: 250-300g) were crossed with male rats and the zero time of pregnancy was detected. Existence of vaginal plug and also sperm in vaginal smear were indicators of mating and pregnancy. Experimental group received 0.05 mg/ml of Morphine in drinking water daily. On embryonic day 19, pregnant animals were anesthetized by Chloroform and embryos were taken out surgically. Weight of the embryos was determined by a digital balance and their length (Crown-Rump, Frontal-Occipital, Biparietal, Abdominal-Transfer and Anterior-Posterior diameters) were determined by a caliper. Then embryos were fixed in Formalin 10% and tissues were processed and sectioned and stained in Hematoxilin & Eosin and Bielschwosky staining methods. These sections were investigated for olfactory bulb development by MOTIC software and light Microscope. Data was analyzed using t-test. Results: The decrease in embryonic weight and their diameter for experiment group was significant. In microscopic study, the increase in thickness of mitral layer and the decrease in total number of Tufted, Mitral and Granular cells in experimental group were significant. Conclusion: This study showed that oral Morphine consumption leads to olfactory bulb defects. Olfactory bulb Morphine rat 2008 3 01 47 55 http://jams.arakmu.ac.ir/article-1-184-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Determining the effect of Body Mass Index and laboratry factors on left ventricular hypertrephy in patiant with systemic hypertension Saeid Sadrnia saeidsadrnia@yahoo.com Ali Chehrei Introduction: Left ventriculor hypertrephy (LVH) is one of the complicotions of systemic hypertension. LVH increases probabiltis of cardiac arrhytmia and cardiovasculer event in hypertensive patiants. In addition to hypertension other factors such as dyslipidemia, hyperglicemia and renal failure can cause LVH. This study was designed to investigate the effects of Body Mass Index (BMI) and some laboratory factors on LVH. Materials and Methods: This is a case-control study in which patients in case group (hypertensive patients with LVH) and patients in control group (hypertensive patients without LVH) were compared for BMI, dyslipidemia, hyperglycemia, and elevated Blood Urea Nitrogen (BUN) and Creatinin. Data was analyzed using Chi square test and logistic regression. Results: BMI with, high blood glucose with, high BUN and Creatinin signiticant affect in LVH presentation in hypertensive patiants. Dyslipidemia had not signiticant affect. Conclusion: In this study BMI, hyperglicemia, high BUN and Creatinin affected LVH presention in hypertensive patiant. So it is recommended that these factors be carfuly monitored and and treated. Hypertension Left Ventricular Hypertrophy Body Mass Index hyperglycemia Blood Urea Nitrogen Creatinine dyslipidemia 2008 3 01 56 62 http://jams.arakmu.ac.ir/article-1-187-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Effect of massage on the duration of first stage of labor Zohre Abasi Abasi-zohreh-55@yahoo.com Zahra Abedian Alireza Fdaii Introduction: Prolonged labor is an important problem during labor which can have undesirable effects on both maternal and fetal health. Shortening the duration of labor has always been one of the aims of obstetricians. Hence, the purpose of this research was to investigate the effect of massage on the duration of labor in women attending to Bentolhoda Maternity Unit in the city of Bojnord, Northern Khorasan, Iran in 2005. Materials and Methods: In this clinical tial study, 62 primiparous women with normal pregnancy were participated. The indications of normal pregnancy included a gestational age of 37-42 weeks, single tone, and vertex presentation. Sampling was done by purposive method. Women were randomly allocated in two groups. The experimental group (n=32) received a 30-minute directional, reasonably firm and rhythmic effleurage massage in the back in each of the three phases of labor. The control group (n=30), did not receive any form of massage and received a routine 30-minutes nursing care in each of the three phases. Measurements were then made for strength, interval and frequency of contractions and the duration of each phase. Data were analyzed using student t, Chi-square and Mann-Whitney tests. Results: Findings showed a significant decrease in the duration of labor after massage sessions. The mean duration of labor for the massage group was 5.75 hourse and for the routine nursing care group 9.15 houres (p=0.001). Conclusion: According to the above results, there was a significant decrease in duration of the first phase of labor in pregnant women receiving massage sessions. Therefore, this method can be used to decrease the period of hospitalization. Massage obstetric labor labor stage first 2008 3 01 63 71 http://jams.arakmu.ac.ir/article-1-188-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Frequency of Celiac disease in rural regions of Arak, 2006 Mohsen Ghasedi Elham Farhadi e.farhadi.as@gmail.com Raza MalekZadeh Ghasem Mosayebi Ali Ghazavi Babak Eshrati Introduction: Celiac disease (CD) or gluten-sensitive enteropathy is a malabsoption of nutrients due to hyoersesitivity of gluten. Some etiologic facrors are environmental, immunologic and genetic factors. The frequancy of Celiac disease is not studied in western regions of Iran, therefore this study is done to determine the frequancy of Celiac disease in general population of rural regions of Arak. Materials and Methods: This is a descriptive, cross-sectional study in which 700 people between 20-56 years old in rural regions of Arak were selected by multistage random sampling (364 male and 336 female). After completing questionnaires, blood samples were collected and serum IgA levels (to rule out IgA deficiency), and serum t-TG Ab were assessed. All cases that had positive serologies and those who had high clinical probability of having Celiac disease underwent second duodenal segment biopsy. Data was presented using mean, standard deviation and frequency distribution. Results: Serum IgA levels were normal in all samples. 8 cases were positive for t-TG Ab, 38 cases had high normal levels of t-TG Ab and the others had less than 6 Au/ml t-TG Ab. Only in patients with high normal serology, histology was positive. 1% (10 in 1000 people) of all studied subjects demonstrated intestinal lesions due to Celiac disease. Most of them were asymptomatic. Conclusion: CD frequency in rural regions of Arak in people between 20-65 years old was 10 among 1000 cases. This frequency is the same as studies done in northern and southern regions of Iran but was higher comparing to the other parts of the word. This amplifiles the importance of screening of CD in Iran. Also the sensitivity and specificity of t-TG Ab was found high because all cases with high normal levels of t-TG Ab were approved by histology. Celiac disease IgA rural region 2008 3 01 72 78 http://jams.arakmu.ac.ir/article-1-189-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Trend of labor progression in multiparous women in Fasa, 2005 Narges Mohammad Salehi Hamid raza Tabatabaee Maryam Raoofi Abolfazl Mohammad beigi amohamadbeigi@yahoo.com Introduction: Labor refers to the chain of physiologic events that allows a fetus to undertake its journey from the uterus to the outside world. Friedman (1954) describes a sigmoid pattern for labor. This study is carried out to identify the trend of labor progression in multiparous women. Materials and Methods: The present cohort study was conducted on 336 multiparous women. In order to assess labor stages, dilatation per unit of time was evaluated in each participant. Participants were divided into four groups: non intervention, induced, sedated, and both intervention groups. The related parameters were evaluated in all groups. Data was analyzed using one way analysis of variance, one sample t-test and mixed model regression models in reverse method for drawing the curve. Results: In all groups, with the increasing expansion of cervix the rate of cervix dilatation was increased. A significant relationship was observed between expansion speed rate in active phase of the first stage and the third stage, with induction of labor (p<0.05). But there was no relationship between the second stage and induction. The mean time of active phase and the second stage in this study was significantly higher than women of Freidman study (3.56 hours in contrast to 2.2 hours and 25 minute in contrast to 18 minute, respectively)(p<0.001). Also in the present study the deceleration phase was not seen. Conclusion: Now the pattern of labor progression differs from Freidman's curve in 1950 and has not the sigmoid shape, and the most important factor affecting latent phase is the dilatation of cervix at the time of admission. So determining a standard curve, without bias, is very difficult, and statistical methods should be used to decrease the effect of confounding factors of participants. Obstetric labor progression multiparity 2008 3 01 79 87 http://jams.arakmu.ac.ir/article-1-190-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Study of the extracellular trans zinc effect on passive avoidance learning in male Wistar rats Reza Mohajerani Mohammad reza Palizvan palizvan@yahoo.com Shahrbanou Oryan Vahab Babapour Introduction: In this study the effect of extracellular trans zinc and voltage sensitive calcium channels on different aspects of learning and memory has been investigated. Materials and Methods: This is an experimental study in which the effect of a calcium channel antagonist (Verapamil) and zinc chelator (Ca-EDTA), on passive avoidance learning (shuttle box apparatus) has been examined by intraperitoneal administration of defferent doses of these drugs. Data was analyzed using one way analysis of variance. Results: Result of intraperitoneal injection of 100 milimolar Ca-EDTA indicated that it has no effect on the acquisition, consolidation, and retrieval of passive avoidance learning. Verapamil (100 and 150 micrograms) as a L-type voltage gated calcium channel antagonist, decreased acquisition and consolidation but not retrieval of passive avoidance behaviour. These effects were dose dependent. The simltaneous effect of Ca-EDTA and verapamil was also studied. Ca-EDTA (100milimolar) and verapamil (100 micrograms) have negative effects on consolidation of passive avoidance learning. Conclusion: Probably, common mechanisms are involved in acquisition and consolidation of passive avoidance learning, and zinc and calium ions play interactive roles in this aspect. Avoidance learning passive zinc extracellular trans calcium channel antagonist 2008 3 01 88 96 http://jams.arakmu.ac.ir/article-1-191-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Designing a model of medical equipment management for Iranian hospitals, 2007 Amir Ashkan Nasiripour drnp20@yahoo.com RahmatAllah Jadidi Introduction: Optimum management of medical equipment in hospital settings has tremendous effects on decreasing costs and providing desired health and treatment services. This research has been undertaken to design a medical equipment management model for public hospitals of Iran. Materials and Methods: In this adaptive research, medical equipment management among United States of America, United Kingdom, Germany, Canada, Australia, Sweden and Italy, which have successful experiences and determined patterns for medical equipment management, are assessed with respect to 6 dimensions as structure, purchase, control, maintenance, training and distribution and according to the shared strategies in the mentioned countries, a model was designed for Iran's public hospitals. This model was validated using expert's survey in DELFI method. Results: In all of the studied countries, the medical equipment engineering unit is established for effective management of medical equipments and in direction with the main purpose of ensuring safety and improving patient care, clinical engineers are being trained. Trainings are designed according to international federation course plan for clinical engineers “which are combination of necessary engineering and managing courses for activities of hospital medical equipment management”. Under study issues include: precise need assessment for medical devices, balancing, use of life span expenditure, stock management, location finding, and needed physical space prediction, selection and purchase committee establishment, entering controls plus reception test, performance and safety control, activities documentation, using computerized systems for preventive maintenance and semi-centered distribution, are among necessary processes in the medical equipment management cycle of under studied countries' hospitals. Conclusion: Management and medical equipment engineering unit establishment in hospitals, selection and purchase committee formation, continuous equipment performance control during calibration process, equipment preventive maintenance according to workforce training schedule, training needed experts, and with respect to the topics of international federation courses for clinical engineering training in universities, will improve medical equipment efficiency in hospitals. Hospital materials management medical equipment hospital 2008 3 01 97 108 http://jams.arakmu.ac.ir/article-1-192-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 Determining the efficacy of Deferiprone (L1) on decreasing ferritin levels of Thalassemia patients in Arak Mozhgan Hashemi mozh-hash@yahoo.com Sharare Khosravi Introduction: Thalassemia patients are transfusion dependent and the consequence of these repeated transfusions is hemosiderosis. Therefore these patients need iron chelator drugs. Desferioxamine is an iron chelator drug that its route of administration is subcutaneous which is very difficult for patients. Deferiprone (L1) is an oral iron chelator drug that is easy to use for thalassemic patients. The aim of this study is the efficacy assessment of L1 on ferritin level in Arak city during 6 months. Materials and Methods: In this before and after clinical trial study, 33 patients underwent treatment with L1, with the dose of 75 mg/kg/day.The mean of ferritin level in patients was measured before and 6 months after receiving L1. Data was analyzed using paired t-test. Results: The mean age of patients was 17.2±1 years (10-34 years old). The mean ferritin level before administration of L1 was 1881±257 mcgr/l and after administration of the drug was 2495±384 which had no significant difference. Side effects were leukopenia (3%), rise of ALT (35%) and increase of AST (60%) which were all transient. Conclusion: Although the level of ferritin increased after the treatment with L1, but there was no significant difference and it seems that the drug can have a good effect in decreasing iron. All of he patients in this study have received the drug for 6 months. Therefore we need other studies with longer duration in order to assess the efficacy of Deferiprone. Deferiprone Deferoxamine Thalassemia Ferritin 2008 3 01 109 116 http://jams.arakmu.ac.ir/article-1-193-en.pdf
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Journal of Arak University of Medical Sciences J Arak Uni Med Sci 1735-5338 2008-644X 2008 11 1 A case report of primary adenocarcinoma of appendix Fathallah Mohaghegh Mohagheghfrt@yahoo.com Introduction: Primary appendiceal adenocarcinoma is rare (less than 250 cases described in the literature). In this article a case of appendiceal carcinoma with peritoneal seeding is reported. Case: The patient is a 38 years old man presented with pain, tenderness and rebound in the lower quadrant of the abdomen. These findings suggested acute appendicitis. Emergency laparotomy showed inflamed appendix, without adhesion to the surrounding tissue or perforation. Appendectomy was performed. The histologic diagnosis revealed a moderately differentiated appendiceal adenocarcinoma. The tumour had infiltrated up to serouca of the appendix. The patient was reffered to oncology center but due to refusing of patient for further evaluation, six months later he was admitted with dyspnea, abdominal pain and prorusion. Clinical examination and diagnostic work ups showed massive exudative ascites. The patient was admitted to the oncology ward of Vali-e-Asr hospital with the diagnosis of appendiceal adenocarcinoma with peritoneal involvement. Conclusion: In case of acute appendicitis, the possibility of appendiceal adenocarcinoma should be considered Adenocarcinoma appendix appendicitis appendectomy 2008 3 01 117 122 http://jams.arakmu.ac.ir/article-1-195-en.pdf