دوره 21، شماره 5 - ( دوماهنامه مهر و آبان 1397 )                   جلد 21 شماره 5 صفحات 120-110 | برگشت به فهرست نسخه ها

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Ghazavi A, Ganji A, Khaki M, Mosayebi G. Existential Philosophy of the Immune System: Defense or Homeostasis?. J Arak Uni Med Sci 2018; 21 (5) :110-120
URL: http://jams.arakmu.ac.ir/article-1-5863-fa.html
قضاوی علی، گنجی علی، خاکی محسن، مسیبی قاسم. فلسفه وجودی سیستم ایمنی: دفاع یا هوموستاز؟. مجله دانشگاه علوم پزشكي اراك. 1397; 21 (5) :110-120

URL: http://jams.arakmu.ac.ir/article-1-5863-fa.html


1- گروه ایمونولوژی و میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران. مرکز تحقیقات طب سنتی و مکمل، دانشگاه علوم پزشکی اراک، اراک، ایران.
2- گروه ایمونولوژی و میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران.
3- گروه ایمونولوژی و میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران. مرکز تحقیقات پزشکی و مولکولی، دانشگاه علوم پزشکی اراک، اراک، ایران. ، ghasemmosayebi@arakmu.ac.ir
چکیده:   (3156 مشاهده)
زمینه و هدف: در مورد پیدایش سیستم ایمنی دو فلسفه مطرح است: فلسفه دفاعی و فلسفه هوموستاز. در این مقالهی مروری، نگاهی فراتر از پیش به فلسفه وجودی سیستم ایمنی خواهیم داشت، نگاهی که در آن نقش دفاعی سیستم ایمنی، تنها بخشی از وظایف هوموستاتیک آن قلمداد میشود.
مواد و روشها: جستجوی مقالات در مدلاین با استفاده از کلیدواژههای Homeostasis، Immunculus، Natural autoantibody،Evaluation  و Immune system انجام شد.
یافتهها: هوموستاز مهمترین وظیفه سیستم ایمنی و فلسفه پیدایش این سیستم است، بهطوریکه نقش دفاعی آن نیز تنها بخشی از وظایف هموستاتیک میباشد. آنتیبادیهای طبیعی با نشان دادن تغییرات کیفی و کمی در ترکیب آنتی ژنیک بدن، این وظیفه را تحت عنوان انعکاس ایمنی ایفا میکنند و میتوانند به عنوان نشانگرهایی جهت پیشآگهی از بیماریهای مختلف عمل نمایند.
نتیجهگیری: اگرچه پیشرفتهای زیادی در توضیح نقش هموستاتیک سیستم ایمنی صورت گرفته است، ولی هنوز جای کار بسیاری برای مشخص شدن تمامی ابعاد آن وجود دارد.

 
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نوع مطالعه: مقاله مروری | موضوع مقاله: عمومى
دریافت: 1397/5/2 | پذیرش: 1397/6/19

فهرست منابع
1. Zaccone G, Mauceri A, Maisano M, Giannetto A, Parrino V, Fasulo S. Innervation and neurotransmitter localization in the lung of the Nile bichir Polypterus bichir bichir. The Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology: Advances in Integrative Anatomy and Evolutionary Biology. 2007; 290(9):1166-77.
2. Flajnik MF. Re-evaluation of the immunological Big Bang. Current Biology. 2014; 24(21):R1060-R5.
3. Matsunaga T, Rahman A. What brought the adaptive immune system to vertebrates?‐The jaw hypothesis and the seahorse. Immunological reviews. 1998; 166(1):177-86.
4. Karimi K, Bienenstock J, Wang L, Forsythe P. The vagus nerve modulates CD4+ T cell activity. Brain, behavior, and immunity. 2010; 24(2):316-23.
5. Kim MS, Yan J, Wu W, Zhang G, Zhang Y, Cai D. Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis. Nature immunology. 2015; 16(5):525.
6. Green SA, Simoes-Costa M, Bronner ME. Evolution of vertebrates as viewed from the crest. Nature. 2015; 520(7548):474.
7. Flajnik MF, Kasahara M. Origin and evolution of the adaptive immune system: genetic events and selective pressures. Nature Reviews Genetics. 2010; 11(1):47.
8. Boehm T, Hirano M, Holland SJ, Das S, Schorpp M, Cooper MD. Evolution of alternative adaptive immune systems in vertebrates. Annual review of immunology. 2018; 36:19-42.
9. Kamminga H. Metchnikoff and the origins of immunology: From metaphor to theory: Alfred I. Tauber and Leon Chernyak Monographs on the History and Philosophy of Biology (Oxford: Oxford University Press, 1991), xviii+ 247 pp. ISBN 0-19-506447-X Cloth£ 35.00. 1994.
10. Tauber AI. The molecularization of immunology. The Philosophy and History of Molecular Biology: New Perspectives. 2001:125-69.
11. Poletaev AB, Churilov L, Stroev YI, Agapov M. Immunophysiology versus immunopathology: Natural autoimmunity in human health and disease. Pathophysiology. 2012; 19(3):221-31.
12. Matzinger P. The danger model: a renewed sense of self. Science. 2002; 296(5566):301-5.
13. Matzinger P. The danger model. Vox Sanguinis. 2004; 87:18-.
14. Marques RE, Marques PE, Guabiraba R, Teixeira MM. Exploring the homeostatic and sensory roles of the immune system. Frontiers in Immunology. 2016; 7:125.
15. Reyniers JA. Germfree Vertebrates: Present Status: This Series of Papers is the Result of a Conference on Germfree Vertebrates: Present Status, Held and Supported Conjointly by the New York Academy of Sciences and the Damon Runyon Memorial Fund for Cancer Research, Inc., New York, NY, May 15 and 16, 1958. 1959.
16. Wrona D. Neural–immune interactions: an integrative view of the bidirectional relationship between the brain and immune systems. Journal of neuroimmunology. 2006; 172(1-2):38-58.
17. Taniguchi Y, Yoshioka N, Nakata K, Nishizawa T, Inagawa H, Kohchi C, et al. Mechanism for maintaining homeostasis in the immune system of the intestine. Anticancer research. 2009; 29(11):4855-60.
18. Eberl G. A new vision of immunity: homeostasis of the superorganism. Mucosal immunology. 2010; 3(5):450.
19. McFall-Ngai M. Adaptive immunity: care for the community. Nature. 2007; 445(7124):153.
20. Poletaev A, Osipenko L. General network of natural autoantibodies as immunological homunculus (Immunculus). Autoimmunity Reviews. 2003; 2(5):264-71.
21. M B. Les antihemolysines naturelles. Ann Inst Pasteur. 1901; 15:758-63.
22. Lacroix-Desmazes S, Kaveri SV, Mouthon L, Ayouba A, Malanchère E, Coutinho A, et al. Self-reactive antibodies (natural autoantibodies) in healthy individuals. Journal of immunological methods. 1998; 216(1-2):117-37.
23. Ebrahimnezhad S, Jazayeri M, Hassanian SM, Avan A. Current status and prospective regarding the therapeutic potential of natural autoantibodies in cancer therapy. Journal of cellular physiology. 2017; 232(10):2649-52.
24. Bassaro L, Russell SJ, Pastwa E, Somiari SA, Somiari RI. Screening for Multiple Autoantibodies in Plasma of Patients with Breast Cancer. Cancer Genomics-Proteomics. 2017; 14(6):427-35.
25. Casali P, Notkins AL. CD5+ B lymphocytes, polyreactive antibodies and the human B-cell repertoire. Immunology today. 1989; 10(11):364-8.
26. Bendtzen K, Svenson M, Jonsson V, Hippe E. Autoantibodies to cytokines--friends or foes? Immunology today. 1990; 11(5):167-9.
27. Lacroix-Desmazes S, Kaveri SV, Mouthon L, Ayouba A, Malanchere E, Coutinho A, et al. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J Immunol Methods. 1998; 216(1-2):117-37.
28. Nagele EP, Han M, Acharya NK, DeMarshall C, Kosciuk MC, Nagele RG. Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease. PloS one. 2013; 8(4):e60726.
29. Hamanova M, Chmelikova M, Nentwich I, Thon V, Lokaj J. Anti-Gal IgM, IgA and IgG natural antibodies in childhood. Immunology letters. 2015; 164(1):40-3.
30. Kashiwakura J, Okayama Y, Furue M, Kabashima K, Shimada S, Ra C, et al. Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens. Allergy, asthma & immunology research. 2012; 4(6):332-40.
31. Koelsch K, Zheng NY, Zhang Q, Duty A, Helms C, Mathias MD, et al. Mature B cells class switched to IgD are autoreactive in healthy individuals. The Journal of clinical investigation. 2007; 117(6):1558-65.
32. Coutinho A. Simple developmental programs of gene expression and cellular composition of lymphoid organs at the origin of natural tolerance. Research in immunology. 1995; 146(4-5):321-32.
33. Penfield W, Rasmussen T, Erickson T. The cerebral cortex of man, a clinical study of localization of function. LWW; 1954.
34. Cohen IR, Young DB. Autoimmunity, microbial immunity and the immunological homunculus. Immunology today. 1991; 12(4):105-10.
35. Gonzalez G, Montero E, Leon K, Cohen I, Lage A. Autoimmunization to epidermal growth factor, a component of the immunological homunculus. Autoimmunity reviews. 2002; 1(1-2):89-95.
36. Dewey RA. Psychology: an introduction: Russ Dewey; 2007.
37. Rogers J, Glotz D, Zanetti M. Cross-Reacting And Regulatory Idiotypes On Autoantibodies: Effect On Regulation Of Autoimmunity. Biological Application of Anti-Idiotypes: CRC Press. 2018; 111-22.
38. Zaichik A, Churilov LP, Utekhin VJ. Autoimmune regulation of genetically determined cell functions in health and disease. Pathophysiology. 2008; 15(3):191-207.
39. Poletaev A, Osipenko L. General network of natural autoantibodies as immunological homunculus (Immunculus). Autoimmun Rev. 2003; 2(5):264-71.
40. Poletaev A. How the Phenomenon of Immune Reflexion can be used by Preventive Medicine. Adv Biomed Res Innov 1: 1. of. 2018; 2:2.
41. Favaloro B, Allocati N, Graziano V, Di Ilio C, De Laurenzi V. Role of apoptosis in disease. Aging (Albany NY). 2012; 4(5):330.
42. Poletaev AB, Morozov SG. Changes of maternal serum natural antibodies of IgG class to proteins MBP, S100, ACBP14/18 and MP65 and embryonic misdevelopments in humans. Human antibodies. 2000; 9(4):215-21.
43. Poletaev AB, Morozov SG, Gnedenko BB, Zlunikin VM, Korzhenevskey DA. Serum anti-S100b, anti-GFAP and anti-NGF autoantibodies of IgG class in healthy persons and patients with mental and neurological disorders. Autoimmunity. 2000; 32(1):33-8.
44. Kovalev I, Polevaya OY. Biochemical Principles of Immunity against Low Molecular Weight Chemical Compounds. Nauka, Moscow; 1985.
45. Baumgarth N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nature Reviews Immunology. 2011; 11(1):34.
46. Grönwall C, Vas J, Silverman GJ. Protective roles of natural IgM antibodies. Frontiers in immunology. 2012; 3:66.
47. Pedersen J, Gentry-Maharaj A, Fourkala E, Dawnay A, Burnell M, Zaikin A, et al. Early detection of cancer in the general population: a blinded case–control study of p53 autoantibodies in colorectal cancer. British journal of cancer. 2013; 108(1):107.
48. Cohen IR. Activation of benign autoimmunity as both tumor and autoimmune disease immunotherapy: a comprehensive review. Journal of autoimmunity. 2014; 54:112-7.
49. Kit Y. Anti-DNA (“Cationic”) and Ani-Histone (“Anionic”) Auto-Antibodies: Two Sides of One Coin? Journal of Translational Proteomics Research. 2017; 3:1-5.
50. Grabar PN. [Autoantibodies and immunologic theories]. Ontogenez. 1975; 6(2):115-26.
51. Lobo PI. Role of natural IgM autoantibodies (IgM-NAA) and IgM anti-leukocyte antibodies (IgM-ALA) in regulating inflammation. IgM and Its Receptors and Binding Proteins: Springer. 2017: 89-117.
52. Avrameas ES, Alexopoulos H, Moutsopoulos HM. Natural autoantibodies: An undersugn hero of the immune system and autoimmune disorders-A point of view. Frontiers in immunology. 2018; 9:1320.
53. Bendtzen K, Svenson M, Jønsson V, Hippe E. Autoantibodies to cytokines-friends or foes? Immunology today. 1990; 11:167-9.
54. Lobo PI. Role of natural autoantibodies and natural IgM anti-leucocyte autoantibodies in health and disease. Frontiers in immunology. 2016; 7:198.
55. Griffin DO, Holodick NE, Rothstein TL. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70−. Journal of Experimental Medicine. 2011; 208(1):67-80.
56. Wang BS, Lumanglas AL, Szewczyk E, McWilliams W, Loullis CC, Hart IC. A proposed mechanism of action of a growth hormone-specific monoclonal antibody in the enhancement of hormonal activity. Molecular immunology. 1992; 29(3):313-7.
57. Borkowski A, Gyling M, Muquardt C, Body JJ, Leclercq G. Estrogen-like activity of a subpopulation of natural antiestrogen receptor autoantibodies in man. Endocrinology. 1991; 128(6):3283-92.
58. McMahon SB, La Russa F, Bennett DL. Crosstalk between the nociceptive and immune systems in host defence and disease. Nature Reviews Neuroscience. 2015; 16(7):389.
59. Zavdy O, Shoenfeld Y, Amital H. Natural Autoantibodies—Homeostasis, Autoimmunity, and Therapeutic Potential. Autoantibodies (Third Edition): Elsevier. 2014; 21-33.
60. Hill RA, Flint DJ, Pell JM. Antibodies as molecular mimics of biomolecules: roles in understanding physiological functions and mechanisms. Advances in physiology education. 2008; 32(4):261-73.
61. Routsias JG, Kyriakidis NC, Friedman DM, Llanos C, Clancy R, Moutsopoulos HM, et al. Association of the idiotype:antiidiotype antibody ratio with the efficacy of intravenous immunoglobulin treatment for the prevention of recurrent autoimmune-associated congenital heart block. Arthritis and rheumatism. 2011; 63(9):2783-9.
62. Poletaev AB, Churilov LP, Stroev YI, Agapov MM. Immunophysiology versus immunopathology: Natural autoimmunity in human health and disease. Pathophysiology. 2012; 19(3):221-31.
63. Vani J, Elluru S, Negi VS, Lacroix-Desmazes S, Kazatchkine MD, Bayry J, et al. Role of natural antibodies in immune homeostasis: IVIg perspective. Autoimmun Rev. 2008; 7(6):440-4.
64. Shoenfeld Y, Meroni PL, Gershwin ME. Autoantibodies: Newnes; 2013.

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