دوره 21، شماره 5 - ( دوماهنامه مهر و آبان 1397 )                   جلد 21 شماره 5 صفحات 110-120 | برگشت به فهرست نسخه ها

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Ghazavi A, Ganji A, Khaki M, Mosayebi G. Existential Philosophy of the Immune System: Defense or Homeostasis?. J Arak Uni Med Sci. 2018; 21 (5) :110-120
URL: http://jams.arakmu.ac.ir/article-1-5863-fa.html
قضاوی علی، گنجی علی، خاکی محسن، مسیبی قاسم. فلسفه وجودی سیستم ایمنی: دفاع یا هوموستاز؟. مجله دانشگاه علوم پزشكي اراك. 1397; 21 (5) :110-120

URL: http://jams.arakmu.ac.ir/article-1-5863-fa.html


1- گروه ایمونولوژی و میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران. مرکز تحقیقات طب سنتی و مکمل، دانشگاه علوم پزشکی اراک، اراک، ایران.
2- گروه ایمونولوژی و میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران.
3- گروه ایمونولوژی و میکروبیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی اراک، اراک، ایران. مرکز تحقیقات پزشکی و مولکولی، دانشگاه علوم پزشکی اراک، اراک، ایران. ، ghasemmosayebi@arakmu.ac.ir
چکیده:   (394 مشاهده)
زمینه و هدف: در مورد پیدایش سیستم ایمنی دو فلسفه مطرح است: فلسفه دفاعی و فلسفه هوموستاز. در این مقالهی مروری، نگاهی فراتر از پیش به فلسفه وجودی سیستم ایمنی خواهیم داشت، نگاهی که در آن نقش دفاعی سیستم ایمنی، تنها بخشی از وظایف هوموستاتیک آن قلمداد میشود.
مواد و روشها: جستجوی مقالات در مدلاین با استفاده از کلیدواژههای Homeostasis، Immunculus، Natural autoantibody،Evaluation  و Immune system انجام شد.
یافتهها: هوموستاز مهمترین وظیفه سیستم ایمنی و فلسفه پیدایش این سیستم است، بهطوریکه نقش دفاعی آن نیز تنها بخشی از وظایف هموستاتیک میباشد. آنتیبادیهای طبیعی با نشان دادن تغییرات کیفی و کمی در ترکیب آنتی ژنیک بدن، این وظیفه را تحت عنوان انعکاس ایمنی ایفا میکنند و میتوانند به عنوان نشانگرهایی جهت پیشآگهی از بیماریهای مختلف عمل نمایند.
نتیجهگیری: اگرچه پیشرفتهای زیادی در توضیح نقش هموستاتیک سیستم ایمنی صورت گرفته است، ولی هنوز جای کار بسیاری برای مشخص شدن تمامی ابعاد آن وجود دارد.

 
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نوع مطالعه: مقاله مروری | موضوع مقاله: عمومى
دریافت: ۱۳۹۷/۵/۲ | پذیرش: ۱۳۹۷/۶/۱۹

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