Volume 26, Issue 6 (February & March 2024)
J Arak Uni Med Sci 2024, 26(6): 61-67 |
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Hajivand M, Fathi M, Gorgin Z, Rezaei R. the effect of swimming training on the expression of caspase 1 and AIM2 protein in Hippocampus male wistar rats. J Arak Uni Med Sci 2024; 26 (6) :61-67
URL: http://jams.arakmu.ac.ir/article-1-7624-en.html
URL: http://jams.arakmu.ac.ir/article-1-7624-en.html
1- Lorestan university
2- Lorestan university ,rezaei.r@lu.ac.ir
2- Lorestan university ,
Abstract: (671 Views)
Backgrand: Inflammation can cause damage to the central nervous system, leading to neuropathological diseases such as stroke, pain, schizophrenia, and Alzheimers. AIM2 is a member of the PYHIN hematopoietic nuclear protein family that binds to cytosolic DNA and activates caspase-1, one of the inflammatory-mediated caspases that activates pro-inflammatory cytokines. The aim of this research is to investigate the effect of a swimming training course on the expression of caspase-1 and AIM2 proteins in the hippocampus of male Wistar rats.
Method: The statistical population of this study included 16 male Wistar rats (6 weeks) divided into two groups: a group without training and an endurance training group. Eight rats were placed in each group. The group without training did not engage in any sports activities, while the training group participated in a swimming training session. After a 4-day familiarization period, the rats swam for 30 minutes from the fifth day. Independent T-test was used to evaluate the interventions, and all statistical calculations were done using SPSS statistical software.
Results: The results of this research showed that exercise caused a significant decrease in the level of caspase-1 and AIM2 proteins in the hippocampus of male Wistar rats.
Discussion: Overall, this study suggests that endurance swimming training can effectively reduce caspase-1 and AIM2 proteins. Therefore, it is possible that exercise, by reducing inflammatory factors, can be a potential treatment for diseases caused by inflammation, such as sclerosis, diabetes, cancer, and Alzheimers.
Method: The statistical population of this study included 16 male Wistar rats (6 weeks) divided into two groups: a group without training and an endurance training group. Eight rats were placed in each group. The group without training did not engage in any sports activities, while the training group participated in a swimming training session. After a 4-day familiarization period, the rats swam for 30 minutes from the fifth day. Independent T-test was used to evaluate the interventions, and all statistical calculations were done using SPSS statistical software.
Results: The results of this research showed that exercise caused a significant decrease in the level of caspase-1 and AIM2 proteins in the hippocampus of male Wistar rats.
Discussion: Overall, this study suggests that endurance swimming training can effectively reduce caspase-1 and AIM2 proteins. Therefore, it is possible that exercise, by reducing inflammatory factors, can be a potential treatment for diseases caused by inflammation, such as sclerosis, diabetes, cancer, and Alzheimers.
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