Volume 15, Issue 8 (January 2013)                   J Arak Uni Med Sci 2013, 15(8): 61-67 | Back to browse issues page

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Ghorbani Birgani A, Abedi P, Zare K, Assadpoor S. The effect of berberine on patients with psoriasis. J Arak Uni Med Sci. 2013; 15 (8) :61-67
URL: http://jams.arakmu.ac.ir/article-1-1568-en.html
1- Master of Nursing, Department of Nursing & Midwifery, Gachsaran branch, Islamic Azad University, Gachsaran, Iran. , Alenc5@gmail.com
2- Faculty Member of Nursing and Midwifery School, Ahvaz Joundisahapour University of Medical Sciences, Iran, Nursing and Midwifery School, Ahvaz Joundisahapour University of Medical Sciences, Iran.
3- Master of Nursing, Department of Nursing & Midwifery, Gachsaran branch, Islamic Azad University, Gachsaran, Iran., Department of Nursing & Midwifery, Gachsaran branch, Islamic Azad University, Gachsaran, Iran.
Abstract:   (10631 Views)
Background: Psoriasis is a common chronic skin disease which usually appears as white and silvery spots on the skin. The purpose of this study is to investigate the effect of berberine on patients with psoriasis. Materials and Methods: This double-blind clinical trial was conducted on 60 psoriasis patients who referred to Imam Khomeini Hospital, Ahvaz, between July and December 2011. The patients were randomly divided into two equal groups that applied berberine and placebo to the treatment of their lesions twice a day. Lesions severity rate in the patients was assessed 7 times using a Psoriasis Area Severity Index (PASI). Data were analyzed by ANOVA with repeated measurements and Chi-square using SPSS software. Results: After 6 months, severity of lesions showed a significant decrease in the group receiving the berberine cream compared with the placebo group so that the mean PASI score of the group receiving berberine decreased from 3.99 to 2.11 while in the placebo group this decreased from 3.98 to 3.71. Mean difference in PASI score was not significant before receiving the treatment till the third month in berberine and placebo groups, but in the fourth to sixth months it was statistically significant (p=0.013). Conclusion: Berberine cream was more effective than the placebo in reduction of skin lesions of psoriasis patients. Therefore, it is recommended that plant-based drugs, like berberine, be used more besides the main medications of patients.
Keywords: Berberine, psoriasis, PASI
Full-Text [PDF 328 kb]   (2095 Downloads)    
Subject: General
Received: 2012/02/22 | Accepted: 2012/09/20
* Corresponding Author Address: Department of Nursing & Midwifery, Gachsaran branch, Islamic Azad University, Gachsaran, Iran.

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