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Background: Pyoderma gangrenosum (PG) is an uncommon, non-infectious, neutrophilic, ulcerative disease with typically starts with pustules which rapidly evolve to painful ulcers with undermined violaceous borders. The diagnosis of PG is based on clinical features and requires exculusion of other conditions that produce ulcerations .PG is associated with a variety of systemic diseases that the most commonly of them is include inflammatory bowel diseases, leukaemia, myeloma, monoclonal gammopathies, chronic active hepatitis, systemic lupus erythmatous and arthritis. Two cases of PG with haemolytic anemia have been reported and this patient is third one. Case: patien was a 19-year –old girl, with haemolytic anaemia from 15 years ago. Who was reffered with an ulcer, 2×3 cm in diameter, on her lower right leg with violaceous border and on her lower left leg with painful haemorrhagic bulla 4×6 cm in diameter. Conclusion: Because, PG in many cases is associated with an underlying disease in these patients, search for finding possible underlying diseases is necessary

Keywords: Neutrophilic dermetosis, Pyoderms gangernosum, Hamoytic anemia

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