Volume 19, Issue 5 (8-2016)                   J Arak Uni Med Sci 2016, 19(5): 31-41 | Back to browse issues page

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Hajizadeh Moghaddam A, kianmehr A. The Protective Effect of Quince (Cydonia oblonga Miller) Leaf Extract on Locomotor Activity and Anxiety-Like Behaviors in a Ketamine Model of Schizophrenia. J Arak Uni Med Sci 2016; 19 (5) :31-41
URL: http://jams.arakmu.ac.ir/article-1-3969-en.html
1- Department of Biology, University of Mazandaran, Babolsar, Iran. , a.hajizadeh@umz.ac.ir
2- Department of Biology, University of Mazandaran, Babolsar, Iran.
Abstract:   (4366 Views)

Background:  Schizophrenia is a chronic debilitating psychiatric disorder affecting 1% of the population worldwide. As for key role of free radicals in the development of this disease and that Quince leaf is a natural source of antioxidant substances, this study was aimed to evaluate the protective effects of Quince leaf extract on locomotor activity and anxiety-like behaviors by an intraperitoneal injection of ketamine in male mice in a ketamine model of schizophrenia.

Materials and Methods: In the experimental research, male adult mice were divided into six groups including: control, Sham (received water orally and saline intraperitoneally), psychosis group (received 10 mg/kg/day ketamine i.p. for 10 days) and treated psychosis groups (received 50, 100 and 150 mg/kg/day). Treated groups received hydroalcoholic Quince leaf extract orally for 3 weeks before injection of ketamine. Extract gavages continue for 5 days after the last ketamine injection. Locomotor activity and anxiety-like behavioral changes were measured in the open-field test.

Results: The results showed that chronic administration of ketamine increases horizontal locomotor activity and anxiety like behaviors (p≤0.001) and pretreatment of Quince leaf extract effectively decreases horizontal locomotor activity (p<0.001) and increases duration that spends in middle area of Open field (p<0.01) and vertical ocomotor activity(p<0.001).

Conclusion: The results of this research showed that chronic administration of Quince leaf extract improves locomotor disorder and induced anxiety-like behaviors by having antioxidant properties in a ketamine model of schizophrenia.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2015/09/22 | Accepted: 2016/06/5

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