Volume 20, Issue 6 (9-2017)
J Arak Uni Med Sci 2017, 20(6): 54-62 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Alidadiani S, Salehi Z. The Association of VEGF +405 C/G Polymorphism with In vitro Fertilization and Embryo Transfer Outcome (IVF-ET) in Iranian Population. J Arak Uni Med Sci 2017; 20 (6) :54-62
URL: http://jams.arakmu.ac.ir/article-1-5104-en.html
URL: http://jams.arakmu.ac.ir/article-1-5104-en.html
1- Department of Genetics, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
2- Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran ,geneticzs@yahoo.co.uk
2- Department of Biology, Faculty of Basic Sciences, University of Guilan, Rasht, Iran ,
Abstract: (3320 Views)
Abstract
Background: Implantation of an embryo involves a complex sequence of signaling events, consisting of a large number of molecular mediators such as ovarian hormones, cytokines, adhesion molecules and growth factors. Vascular endothelial growth factor (VEGF) is an important angiogenic factor. VEGF is believed to play an important role in the process of implantation. The aim of this study was to evaluate the association of VEGF +405C/G polymorphism and the clinical outcomes of women who underwent IVF-ET procedures.
Materials and Methods: One hundred women with previous IVF-ET failures and 100 pregnant women as controls were genotyped for VEGF +405 C/G by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analysis was performed using the MedCalc software.
Results: Our results indicated a higher prevalence of the VEGF +405 GG genotype and G allele in patients with history of IVF-ET failure (OR=6.90; 95%CI=2.75-17.29; p<0.0001, OR=2.5; 95%CI=1.66-3.76, p<0.0001).
Conclusion: The present study revealed that the VEGF +405 GG genotype was associated with an increased risk of IVF-ET failure. However, further studies in larger populations including other genetic factors are required to achieve a definitive conclusion.
Background: Implantation of an embryo involves a complex sequence of signaling events, consisting of a large number of molecular mediators such as ovarian hormones, cytokines, adhesion molecules and growth factors. Vascular endothelial growth factor (VEGF) is an important angiogenic factor. VEGF is believed to play an important role in the process of implantation. The aim of this study was to evaluate the association of VEGF +405C/G polymorphism and the clinical outcomes of women who underwent IVF-ET procedures.
Materials and Methods: One hundred women with previous IVF-ET failures and 100 pregnant women as controls were genotyped for VEGF +405 C/G by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Statistical analysis was performed using the MedCalc software.
Results: Our results indicated a higher prevalence of the VEGF +405 GG genotype and G allele in patients with history of IVF-ET failure (OR=6.90; 95%CI=2.75-17.29; p<0.0001, OR=2.5; 95%CI=1.66-3.76, p<0.0001).
Conclusion: The present study revealed that the VEGF +405 GG genotype was associated with an increased risk of IVF-ET failure. However, further studies in larger populations including other genetic factors are required to achieve a definitive conclusion.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/05/13 | Accepted: 2017/07/26
Received: 2017/05/13 | Accepted: 2017/07/26
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
