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Volume 13, Issue 4 (1-2011)                   J Arak Uni Med Sci 2011, 13(4): 53-58 | Back to browse issues page

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faraji F, talaie A, saeidi A. The comparison of serum vitamin B12 level in MS patients and normal people. J Arak Uni Med Sci. 2011; 13 (4) :53-58
URL: http://jams.arakmu.ac.ir/article-1-522-en.html
1- , fardin.faraji@yahoo.com
Abstract:   (8946 Views)
Background: Multiple sclerosis (MS) is a demyelinating disease of central nervous system which has different clinical manifestations. Noticing the role of vitamin B12 in synthesis of myelin tissue and the existence of different views about its pathogenesis and causes, we decided to evaluate B12 serum levels in MS patients. Materials and Methods: In a case-control study, 40 patients with definite clinical diagnosis of MS and 80 traumatic patients hospitalized in the emergency ward of Vali-asr Hospital of Arak (the control group) were chosen. The level of blood vitamin B12 was measured for all the subjects through the same type of kit and clinical checklist. Data were analyzed through t-test. Results: The mean vitamin B12 serum level in case and control groups were, respectively, 295±133.3 pg/dl and 257.73±91.3 pg/dl which did not indicate a significant difference(p> 0.05). However, in terms of the type of clinical manifestations, the mean vitamin B12 serum level in MS patients showed at least one sensory, motor, or sphinctery symptom lower than the control group. This difference turned out to be significant(p< 0.05). In terms of MRI findings, patients with brainstem and vertebra plucks respectively had the maximum and minimum vitamin B12 serum levels. Conclusion: Although a significant difference was not observed between the mean vitamin B12 serum levels, based on the significant decreases in the serum levels of this vitamin in some of the patients with subtypes of MS, further studies with larger sample sizes and over longer periods of time are suggested.
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Subject: Internal
Received: 2009/11/15

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