Volume 24, Issue 5 (December & January 2021)                   J Arak Uni Med Sci 2021, 24(5): 640-645 | Back to browse issues page

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Azadeh S S, Keshmiri Neghab H. The Potential of the Use of the Flavonoid Fisetin in the Treatment of Coronavirus by Inhibition of Angiotensin Converting Enzyme 2. J Arak Uni Med Sci 2021; 24 (5) :640-645
URL: http://jams.arakmu.ac.ir/article-1-6362-en.html
1- Department of Biology, Faculty of Basic Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran. , sara.azadehhh@gmail.com
2- Department of Photo Healing and Regeneration, Medical Laser Research Center, Yara Institute Academic Center for Education, Culture and Research, Tehran, Iran.
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In December 2019, a new type of coronavirus called COVID-19 was identified as an unknown cause of pneumonia in Wuhan, China. The pandemic virus was transmitted to humans from a type of seafood that could spread significantly among humans in a short time. Clinical signs of coronaviruses include fever, severe sweating, cough, pneumonia, and a weakened immune system, with acute cases leading to death. One of the most important coronavirus receptors in the host cell is the angiotensin 2 converting enzyme. It is noteworthy that the patient’s recovery process increases during the inhibition of angiotensin 2 converter enzyme. Therefore, the administration of drugs that inhibit this enzyme can be effective in recovering a patient with coronavirus. Flavonoids are one the inhibitors of the angiotensin-converting enzyme, which is abundant in fruits and vegetables. Fistula, a type of flavonoid known in nature as an antioxidant and anti-inflammatory agent in the treatment of many, can be effective in the treatment of coronavirus by inhibiting the enzyme converter angiotensin 2.

  1. Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, et al. Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China. Cell Host Microbe. 2020; 27(3):325-8. [DOI:10.1016/j.chom.2020.02.001] [PMID] [PMCID]
  2. Wu J, Feng CL, Xian XY, Qiang J, Zhang J, Mao QX, et al. [Novel coronavirus pneumonia (COVID-19) CT distribution and sign features (Chinese)]. Zhonghua Jie He He Hu Xi Za Zhi. 2020; 43(4):321-6. [DOI:10.3760/cma.j.cn112147-20200217-00106]
  3. Zu ZY, Jiang MD, Xu PP, Chen W, Ni QQ, Lu GM, et al. Coronavirus disease 2019 (COVID-19): A perspective from China. Radiology. 2020; 296(2):E15-25. [DOI:10.1148/radiol.2020200490] [PMID] [PMCID]
  4. Paraiso IL, Revel JS, Stevens JF. Potential use of polyphenols in the battle against COVID-19. Curr Opin Food Sci. 2020; 32:149-55. [DOI:10.1016/j.cofs.2020.08.004] [PMID] [PMCID]
  5. Diaz JH. Hypothesis: Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may increase the risk of severe COVID-19. J Travel Med. 2020; 27(3):taaa041. [DOI:10.1093/jtm/taaa041] [PMID] [PMCID]
  6. Choudhury A, Mukherjee S. In silico studies on the comparative characterization of the interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and human TLRs. J Med Virol. 2020; 92(10):2105-13. [DOI:10.1002/jmv.25987] [PMID] [PMCID]
  7. Batlle D, Wysocki J, Satchell K. Soluble angiotensin-converting enzyme 2: A potential approach for coronavirus infection therapy? Clin Sci. 2020; 134(5):543-5. [DOI:10.1042/CS20200163] [PMID]
  8. Jena AB, Kanungo N, Nayak V, Chainy GB, Dandapat J. Catechin and Curcumin interact with corona (2019-nCoV/SARS-CoV2) viral S protein and ACE2 of human cell membrane: Insights from computational study and implication for intervention. 2020. [DOI:10.21203/rs.3.rs-22057/v1]
  9. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: A dietary antioxidant for health promotion. Antioxid Redox Signal. 2013; 19(2):151-62. [DOI:10.1089/ars.2012.4901] [PMID] [PMCID]
  10. Kumari S. Identification of the potent inhibitors for a Coronavirus Protease-an in-silico approach. 2020; 7(5):5559-67. https://www.irjet.net/archives/V7/i5/IRJET-V7I51066.pdf
  11. Alzaabi MM, Hamdy R, Ashmawy NS, Hamoda AM, Alkhayat F, Khademi NN, et al. Flavonoids are promising safe therapy against COVID-19. Phytochem Rev. 2021:1-22. [DOI:10.1007/s11101-021-09759-z] [PMID] [PMCID]
  12. Oladele JO, Oyeleke OM, Oladele OT, Olowookere BD, Oso BJ, Oladiji AT. Kolaviron (Kolaflavanone), apigenin, fisetin as potential Coronavirus inhibitors: In silico investigation. 2020. [DOI:10.21203/rs.3.rs-51350/v1]

Type of Study: Editorial | Subject: COVID-19
Received: 2020/06/15 | Accepted: 2021/08/8

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