Volume 6, Issue 2 (Summer 2003)
J Arak Uni Med Sci 2003, 6(2): 28-31 |
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Ranjbar A, Pasalar P, Sedighi A R, Abdollahi M, Danesh-Nia J. Induction of Oxidative Stress in Paraquat Herbicide Formulating Workers. J Arak Uni Med Sci 2003; 6 (2) :28-31
URL: http://jams.arakmu.ac.ir/article-1-6761-en.html
URL: http://jams.arakmu.ac.ir/article-1-6761-en.html
1- Toxicologist, Arak University of Medical Sciences, Arak, Iran.
2- Professor, Tehran University of Medical Sciences, Tehran, Iran.
3- Educational Health, Arak University of Paramedical Sciences, Arak, Iran.
2- Professor, Tehran University of Medical Sciences, Tehran, Iran.
3- Educational Health, Arak University of Paramedical Sciences, Arak, Iran.
Abstract: (1483 Views)
Introduction: Production of free radicals and reactive oxygen species is an integral part of aerobic metabolism. Disturbance of the balance between the production of free radicals and antioxidant system against them produces oxidative stress. Paraquat toxicity is induction of oxidative stress. However, the aim of our study was to evaluate oxidative stress in blood samples of workers in a pesticide factory formulating paraquat.
Materials and Methods: In this study we measured lipid peroxidation (LPO) with thiobarbituric assay (TBARS), total antioxident power (FRAP) and SH groups between workers in pesticide factories (case group) and health subjects (control group).
Results: Oxidative stress was significantly higher (p<0.001) in LPO, significantly lower (p<0.001) in TBARS and significantly lower (p<0.001) in SH groups in the case group compared to control group
Conclusion: It is concluded that chronic exposure of workers in their workplace to paraquat producess oxidative stress that could be prevented by well known nutritional antioxidant supplements.
Materials and Methods: In this study we measured lipid peroxidation (LPO) with thiobarbituric assay (TBARS), total antioxident power (FRAP) and SH groups between workers in pesticide factories (case group) and health subjects (control group).
Results: Oxidative stress was significantly higher (p<0.001) in LPO, significantly lower (p<0.001) in TBARS and significantly lower (p<0.001) in SH groups in the case group compared to control group
Conclusion: It is concluded that chronic exposure of workers in their workplace to paraquat producess oxidative stress that could be prevented by well known nutritional antioxidant supplements.
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