Volume 7, Issue 4 (Winter 2004)                   J Arak Uni Med Sci 2004, 7(4): 7-13 | Back to browse issues page

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Roghani M, Baluch Nejad Mojarad T. The Effect of Beta Vulgaris on Nociception in Male Diabetes Rats. J Arak Uni Med Sci 2004; 7 (4) :7-13
URL: http://jams.arakmu.ac.ir/article-1-6817-en.html
Abstract:   (1405 Views)
Introduction: Experimental  animals  like  diabetes  rats  display  an  augmented  nociceptive  response  to  chemical, mechanical  and  thermal  stimuli  in  long  term. Furthermore, hyperalgesia  is  one  of  the  major  symptoms  of  diabetic  neuropathy  in  some  patients. Considering  the antidiabetic  potential  of  chard, this  study  was  carried  out  to  evaluate  the  possible  analgesic  effect  of  chard-mixed  food  intake  in  male  streptozotocin-induced  diabetic  rats.
Materials  and Methods: In  this  study  rats  were  randomly  divided  into  control, chard-treated  control, salicylate-treated control, diabetic, and  chard-treated  diabetic  groups. At  the  end  of  experiment, nociceptive  response  was  evaluated  in  both  acute  and  chronic  phases  of  the  standard  formalin   test  based  on  a  four  level  scale.
Results: Results  showed  that  there  was  a  significant  increase  in  the  number  of  pain  scores  in  both  acute  and  chronic  phases  in  diabetic  rats, and  administration  of  chard  for  one  month  did  not  significantly  reduce  the  pain  scores  in  both  phases  of  the  test.  Meanwhile, sodium  salicylate  as  positive  control, only  reduced  this  score  in  the  second  phase.
Conclusion: It  can  be  concluded  that  oral  administration  of  chard  for  one  month  despite  of  its  antidiabetic  potential  could  not  significantly  reduce  the  nociceptive  responses  in  diabetic  rats.
 
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Subject: General
Received: 2021/01/30 | Accepted: 2004/12/30

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