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Showing 3 results for Khajehpour
Involvement of Opioid Receptors in the Anticonvulsant Effect of Progesterone in Ovariectomized Mice
Lotfollah Khajehpour, Hosein Najafzadeh Varzi , Mahnaz Kesmati, Fahimeh Hasanvand,
Volume 16, Issue 2 (5-2013)
Abstract

Background: Progesterone is a female steroid hormone that has a potent anticonvulsant effect on human and animal. The aim of this study was to investigate the involvement of opioid receptors in the anticonvulsant effect of progesterone on ovariectomized mice.

Materials and Methods: In this experimental study, all animals were ovariectomized. After two weeks, they received an intraperitoneal (i.p.) injection of drugs (progesterone and naloxone) or saline. The animals also received a subcutaneous injection of strychnine for induction of convulsive seizures, 30 minutes after administration of drugs or saline. For evaluation of convulsion in the animals, convulsion onset time, convulsion duration, the number of seizures, and death time were recorded.

Results: Progesterone (25 and 50 mg/kg, i.p.) decreased the strychnine-induced convulsion. The anticonvulsant effect of 50 mg/kg of progesterone was abolished by naloxone (5 mg/kg, i.p.) injection, whereas administration of the same doses of naloxone alone did not affect strychnine-induced convulsion.

Conclusion: These results suggest that opioid receptors may play an important role in the anticonvulsant effect of progesterone.


Involvement of Opioid Receptors and Ascorbic Acid in the Improvement of Anxiety-Induced Nicotine in Adult Male Mice
Sana Alboghobeysh, Lotfollah Khajehpour, Mahnaz Kesmati,
Volume 21, Issue 3 (6-2018)
Abstract
Background and Aim: Anxiety is an adaptation response that is created in response to multiple physiological and environmental stresses. It is clear that involvement of various neurotransmitter systems has important role in the anxiety process. Vitamin C is a water-soluble antioxidant that plays a role in many physiological reactions in the body. On the other hand, nicotine, which increases with tobacco intake, has an anxiogenic effect. Naloxone, as an opioid receptor antagonist, also plays an important role in the development of anxiety behavior. The aim of this study was to investigate the role of naloxone-co-administered vitamin C on anxiety induced nicotine.
Materials and Methods: 84 male mice (30 ± 2 gr) were randomly divided into 12 groups. Anxiety test was performed 30 minutes after intraperitoneal injection of drugs by an elevated plus maze apparatus for 5 minutes. Anxiety indices such as percentage of open arm entry (OAE%) and percentage of time staying in the open arm (OAT%) were recorded and evaluated.
Findings: In this research, injection of nicotine (0.8 mg/kg, ip) increased anxiety behaviors. Vitamin C (80 mg/kg, ip) improved the nicotine-induced anxiety. This effect of vitamin C was inhibited by ineffective dose of naloxone (4 mg/kg, ip).
Conclusion: It seems that vitamin C decreases anxiety behavior of nicotine in the presence of opioid receptors.

The Study of Effect of Nilutamide (An Androgen Receptor Antagonist) on Spatial Learning And Memory in Adolescent Male Rats
Zahra Salimi , Lotfollah Khajehpour , Farshad Moradpour , Ahmad Ali Moazedi , Ali Pourmotabbed ,
Volume 22, Issue 3 (8-2019)
Abstract
Background and Aim: Nilutamide is a pure non-steroidal antiandrogen that is used in the treatment of advanced-stage (metastatic) prostate cancer and acts as a potent and selective antagonist of the androgen receptors. Previous studies showed that there must be relationship between androgen receptors and cognitive aspects of the brain. Therefore, it seems that nilutamide affects spatial learning and memory through effect on androgen receptors. The aim of this study is to evaluate the effect of nilutamide on spatial localization in the Morris Water Maze and synaptic plasticity at the hippocampus CA1 area of male adolescent rats.
Materials and Methods: In this experimental study, male Wistar rats were randomly divided into 4 groups (n=9). Experimantal groups received vehicle (DMSO 10%) as control groups and different doses of Nilutamide (5, 10 and 15µg/2.5µl). Drug and vehicle were injected for 4 days before training.
Ethical Considerations: This study with research ethics code
EE/ 97, 24, 3061300/ scu.ac.ir has been approved by research ethics committee at Shahid Chamran University of Ahvaz.
Findings: Analysis showed that escape latency and traveled distance for finding hidden platform in the group which received nilutamide (15µg) were significantly lower than of control group at first (p < 0.05) and second (p < 0.01) training days. The results of field potential recording showed that nilutamide had not any significant effect on fEPSP and PS.
Conclusion: The results of peresent study releaved that i.c.v microinjection of nilutamide improved spatial learninig in first and second days, wherease increase of treatment (4 days) not affected spatial learning.

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