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Introduction: Different groups of drugs are used for prevention of migraine headaches. Howevere, there are controversy about the afficacy of these drugs. Furtheremore, the priority of one to other group is not clear. This study was designed therefore, to compare the effects of Propranolol and Nimodipine on sevierity, duration and frequency of migraine headache.
Materials and Methods: In a clinical trial study, 102 patients with migraine headache refered to neurology clinic were chosen. Patients were devided into two drug groups. Group one received 40 mg Propranolol per day and group two received 30 mg Nimodipine. Data was collected by a questionnaire. Patients were asked to record the severity, duration and frequency of their migraine attacks. Data was analysed using t-test. p<0.05 was considered significant.
Results: The duration and severity of migraine attacks in Propranolol group were less compared to Nimodipine group (p<0.05). However, there was no statistical differences in the frequency of migraine of these two groups.
Conclusion: Propranolol seems to be more effective than Nimodipine in prevention of migraine headaches