Volume 8, Issue 2 (7-2005)
J Arak Uni Med Sci 2005, 8(2): 1-7 |
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Aminmansour B, Eslami K. The investigation of Association Between Craniotomy and Serum Cortisol and Growth Hormone Levels in Severe Traumatic Brain Injury. J Arak Uni Med Sci 2005; 8 (2) :1-7
URL: http://jams.arakmu.ac.ir/article-1-161-en.html
URL: http://jams.arakmu.ac.ir/article-1-161-en.html
1- , baminmansour51@yahoo.com
Abstract: (16766 Views)
Introduction: Different hormonal responses may appear in severe head injured patients (including increase in serum Cortisol & GH level). These changes can also be seen in recovery and rehabilitation periods, so influencing the patients, outcome.
Materials and Methods: Forty severely head injured patients, referred to emergency units of Alzahra & Kashani hospitals were studied in a cohort study (selected by convenient sampling) after dividing into two equal groups. Craniotomy was performed for one group and conservative (non-surgical) therapy for the other. In the first and seventh day of admission serum Cortisol and growth hormone were checked (using RIA method). Data was analyzed by paired and student t tests.
Results: There were significant differences between mean of GH in the first and also in the seventh day(both with P<0.05) and between mean of GH and Cortisol from first to seventh day in two study groups(P<0.05). But there were no significant differences between mean of Cortisol in the first or seventh day in two study groups.
Conclusion: Results of this study showed that craniotomy as an independent factor can raise serum GH and Cortisol levels in severely head injured patients.
Materials and Methods: Forty severely head injured patients, referred to emergency units of Alzahra & Kashani hospitals were studied in a cohort study (selected by convenient sampling) after dividing into two equal groups. Craniotomy was performed for one group and conservative (non-surgical) therapy for the other. In the first and seventh day of admission serum Cortisol and growth hormone were checked (using RIA method). Data was analyzed by paired and student t tests.
Results: There were significant differences between mean of GH in the first and also in the seventh day(both with P<0.05) and between mean of GH and Cortisol from first to seventh day in two study groups(P<0.05). But there were no significant differences between mean of Cortisol in the first or seventh day in two study groups.
Conclusion: Results of this study showed that craniotomy as an independent factor can raise serum GH and Cortisol levels in severely head injured patients.
Received: 2009/02/17 | Accepted: 2005/07/15
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