Background: Physical activity and overweight both changethe body homeostasis for this purpose, in this study effect of two models of high and moderate intensity aerobic exercises on the amount of Adiponectin and Resistin were compared inobese and overweight females.

Materials and Methods: In this experimental study, 15 obese and overweight female (Mean age: 22.93±0.54 years weight: 75.15±2.07 kg hight: 160.6±1.38 Cm BMI: 29.24±0.73kg.m-2) were randomly selected as sample. Subjects were placed into high (33 min exercise, 85-90% of max hearat rate) and moderate (41 min exercise, 50-70% of max hearat rate) intensity aerobic exercise groups. Exercises lasted three days a week for eight weeks with an equal volume of consumed energy. In order to analyze data, independent-t test and Repeated Measure analysis of variance were used at a significance level of p<0.05.

Results: The results indicate a significant increase in Adiponectin after eight weeks of high-intensity aerobic exercise compared to moderate-intensity exercise (p=0.02). A significant reduction in fat mass and percentage was observed after moderate intensity exercise (p=0.03), too. In Addition, moderate intensity exercise caused a considerable decrease in Resistin after eight weeks (p=0.06).

Conclusion: High-intensity exercise appears to provide necessary metabolic stress to enhance Adiponectin, even without weight and fat loss.