Volume 16, Issue 8 (11-2013)                   J Arak Uni Med Sci 2013, 16(8): 10-20 | Back to browse issues page

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Pourghassem Gargari B, Dehghan P, Mirtaheri E, Faghfouri Z, Karimi P. Effects of Oligofructose-Enriched Inulin Prebiotic Supplementation on the Lipid Profile and Inflammation in Patients with Type 2 Patients: A Randomized Controlled Trial. J Arak Uni Med Sci. 2013; 16 (8) :10-20
URL: http://jams.arakmu.ac.ir/article-1-2406-en.html
1- Department of Biochemistry and Diet Therapy, Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
2- Nutrition Research Center, Student Research committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran , dehghan.nut@gmail.com
3- Student Research committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:   (8743 Views)

Background: Considering the high prevalence of diabetes and developing cardiovascular diseases via dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of Oligofructose-enriched inulin on serum lipid concentrations and inflammation in type2 diabetic patients.

Materials and Methods: In this clinical trial, 52 patients with type 2 diabetes were assigned to one of two groups. Experimental group (n=27) received 10g/d oligofructose-enriched inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, hs-CRP and serum lipids concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-test and ANCOVA were used to compare comparison of quantitative variables.

Results: At the end of study, we observed significant decrease in total cholesterol (28.00 mg/dL, 14.10%), LDL-c (22.00 mg/dL, 21.7%), TC/HDL-c ratio (-0.73, 20.7%) and LDL-c/HDL-c ratio (-0.55, 27.5%) in oligofructose-enriched inulin compared with the maltodextrin group (p<0.05). Changes in concentrations of triglycerides and high-density lipoprotein were not significant in oligofructose-enriched inulin compared to maltodextrin group.

Conclusion: Oligofructose-enriched inulin supplementation with improving in inflammtion and lipid profile help in management of type 2 diabetes and its complications.

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Type of Study: Original Atricle | Subject: Nutrition
Received: 2013/07/10 | Accepted: 2013/10/23

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