Background: Today, the self-assessed health status is a standard part of epidemiologic and community based studies. The aim of this study is to assess and evaluate the health related quality of life in Qom city.

Materials and Methods: In this descriptive analytical study, population of 340 people over 18 years of Qom city entered the study by filling the questionnaires. A two-part questionnaire was used to collect data which the first part was related to demographic data including age, sex, marital status, education, occupation and place of residence. The second version of the SF-36 questionnaire was used to assess the quality of life.

Results: Generally, considering the all aspects of quality of life in this study, the mean (±SD) of scores was 67.69±14.78. This average was equal to 67.28±15.91 in men and 67.97±14.03 in women which showed a significant difference between them (p =0.030).

Conclusion: In this study the scores of women and single subjects were higher than other people. By the Persian version of 2nd version of SF-36 questionnaire, the quality of life people in different situations might be realized and impact of different demographic factors on quality of life could be measured.