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Background: Green tea, which is the most common drink in the world, has antioxidant and detoxification properties. In this study, the protective effect of green tea extract on nephro-toxicity induced by acetaminophen was investigated. Materials and Methods: 32 male mice were randomly divided into 4 groups. Physiologic serum was administered to the control group for 30 days. Toxic (Acetaminophen) group received physiologic serum for 30 days and on day 30 in addition to physiologic serum, 500 mg/kg acetaminophen was administered orally. Green tea group, instead of water, was fed by 7g/l green tea extract for 30 days. Instead of water, the experiment green tea group was fed with green tea extract for 30 days and 500 mg/kg oral acetaminophen was administered on day 30. On day 31, blood samples were taken from jugular arteries for assaying BUN and Cr. The mice kidneys were cut off and placed in 10% formalin for histopathology assessments. Results: BUN and Cr reduced significantly in the experiment group in comparison with the toxic group. Also, in histopathology assessments, kidney necrosis reduced in experimental group. Conclusion: Green tea seems to have a protective role in acetaminophen induced nephro-toxicity.

Keywords: Acetaminophen, green tea, nephro-toxicity

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