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URL: http://jams.arakmu.ac.ir/article-1-2958-en.html
, Mohsen Soosanabadi1 , Masoud Karimlou2 , Maryem Neishaboury1 , Hamid Reza Khorram Khorshid3
2- Department of Biostatistics and Computer, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
3- Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran ,
Background: Interleukin-16 (IL16) is an important regulator of T cell activation and was reported to act as achemo-attractant agent. There are evidences that IL16 can control the neuroinflammatory processes in Alzheimer’s disease (AD). This study was performed to show whether the IL-16 genepolymorphism, rs11556218 is associated with the risk of sporadic AD in Iranian population.
Materials and Methods: Totally, 148 AD patients and 137non-dementia controls were recruited in this case-control study. Genotyping of rs11556218 T/Gpolymorphism was performed by PCR-RFLP method using the NdeI restriction enzyme.
Results: Statistical analysis of rs11556218 genotypes showed a protective effect against AD in the heterozygote genotype (p=0.001, OR=0.16(0.1-0.28)). Frequency of rs11556218 allele T was higher in patients than controls (p=0.001, OR=0.32(0.21-0.49)).
Conclusion: Our results indicate thatrs11556218 polymorphism has a protective role in the development of sporadic AD in Iranian population.
Received: 2014/05/18 | Accepted: 2014/07/28
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