Background: Celiac disease (CD) is an immune-mediated inflammation of the small intestine which caused by sensitivity to dietary gluten and related proteins in genetically sensitive individuals. This research aimed to investigate of comparison big five factors of personality and early maladaptive schemas among celiac people and normal people.

Materials and Methods: The research method was ex post facto and statistical population included all people with Celiac whose 108 patients were selected by convenient sampling and 108 normal people were selected by convenient in 4 universities of nursing, psychological, literature and accounting of Azad University in Karaj city. Both groups responded brief five factors questionnaire of NEO personality characteristics and Yang’s early maladaptive schemas. Data were analyzed by using independent t-test, analysis of variance and Multivariate Analysis of Variance, Ben Frooni test, Landa test Wickelz and SPSS version 19.

Results: Results indicated that from five main factors of personality, score of psycho -lesion of patient with celiac were more than normal people. Also, patient’s scores in early maladaptive schemas (emotional baffling, lack of trust, fault/shameless, social recluse/ strangeness, attachment/inefficiency, vulnerability toward loss or sickness, not self –maturing/ engaged, failure, fitness/modesty, self-denial, insufficient self-discipline, servitude, self –sacrifice/ aggressive criteria, extreme criticize and emotional inhibition) were higher in comparison with normal people.

Conclusion: This study revealed that according to influence of early maladaptive schemas on celiac sickness, psychological training courses and schema therapy in order to improve emotional and cognitive patterns of these patients.