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Abstract Background: Oxidative stress is strongly related to diabetes and its complications. The aim of this study is to evaluate the effect of experimental diabetes on oxidative stress indexes in the heart tissue and effect of regular swimming on it. Materials and Methods: In experimental-practical study, 40 male Wister rats divided to four groups (n=10): control, control with exercise, diabetic, diabetic with exercise. Diabetes was induced by a single dose injection of Streptozotocin (50mg/Kg, i.p). Study time was 8 weeks. At the end of period, rats were anesthetized by Sodium Pentobarbital (50mg/Kg, i.p) and left ventricle dissociated and maintenance in -80 ºC. Super oxide Dismutase (SOD), Glutathione Peroxides (GPX), Glutathione Reductase (GR) and Catalase (CAT) activities as enzymatic antioxidant status and Malonyl Dealdehyde (MDA) level as index of lipid peroxidation of the tissue in superior layer of tissue homogenization were measured. Results: Diabetes induction significantly reduced CAT and GR activities in heart tissue of diabetic rats compared with control. Also MDA level increased significantly in diabetic-non exercised rats compared with control. Total Glutathione level was similar in all groups. Conclusion: Swimming by preventing in reduction of CAT and GR activities and MDA level of heart tissue has beneficial effects in prevention of cardiovascular complications caused by oxidative stress in diabetes mellitus.

Keywords: Diabetes, Oxidative stress, Swimming, Lipid peroxidation

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