Background: Allergic rhinitis, a chronic inflammatory disease of the respiratory tract, includes an IgE-mediated inflammatory response in the mucosal region of the aerial tubles. Since IL-8 plays a role in increasing the amount of immunoglobulin E and serves as an effective factor in the prevalence of this disease, so this study aims to investing at that whether IL-8 genotypes of 133 C/G polymorphism is associated with the amount of immunoglobulin E in serum in patients with allergic rhinitis.

Materials and Methods: In this analytical and descriptive study, by investigating 130 patients with AR and 62 healthy control volunteers in Chahar Mahalo Bakhtiari province, total level of IgE in serum was determined by ELISA method and then its association with 133 C/G polymorphism was investigated. T-test and chi-square statistical analyzes were performed using SPSS software for statistical analyses.

Results: the total serum IgE level of the patients with GC genotype of 133 C/G SNP were significantly higher regarding normal individuals (p<0.05).

Conclusion: The sigmificant relationship between 133 C/G genotype in IL-8 P gene promoter and increased serum IgE level confirms tht it plays a role in the prevalence of AR.