Background: Nickel and chromium are heavy metals whieh after arriving in biological systems can produce highly reactive free radicals in the body and interact with macromolecules cause damage to them. The purpose of this study, the effect of bilberry and cinnamon extract on blood biochemical factors in workers exposed to nickel and chromium.

Materials and Methods: In this clinical trial, 99 workers were divided into 3 groups: group 1 (control), group 2 workers, welders exposed to nickel and chromium without extract (G) and group 3 workers, welders exposed to nickel and chromium with extracts (B). First biochemical parameters were measured in blood serum. Then the group 3, 2 times a day for four weeks, billberry juice and tea - Cinnamon received. Finally, Biochemical parameters in blood were measured and compared. SPSS software and descriptive statistics (mean±SD), T- independent and one-way ANOVA test were used to analyze the data.

Results: Between group Variance in some biochemical variables between the three groups, control, G and B showed statistically significant differences (p<0.05). Within-group variance was significant in some variables.

Conclusion: After consumption of billberry juice and tea-cinnamon positive changes in biochemical parameters in workers who are exposed to the toxic effects of nickel and chromium was obtained.