Volume 12, Issue 4 (2-2010)                   J Arak Uni Med Sci 2010, 12(4): 36-43 | Back to browse issues page

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Tehranipour М, Khayyatzade J, Ghorbani Z. The effects of maternal diabetes on brain lateral ventricles in newborn rats. J Arak Uni Med Sci 2010; 12 (4) :36-43
URL: http://jams.arakmu.ac.ir/article-1-325-en.html
1- , Ghorbany_z50@yahoo.com
Abstract:   (14106 Views)
Background: Maternal diabetes is associated with an increased risk of several complications in the offspring, such as the growth of congenital disturbances and malformations. In the present study, we examined the effects of maternal hyperglycemia on the volume of brain and lateral ventricle in newborn Wistar rats. Materials and Methods: In this experimental study, on the 7th day of pregnancy, hyperglycemia was induced by a single injection (i.p.) of streptozotocin (55 mg kg-1) and the animals in control group were given an equal volume of citrate buffer. After parturition on the first day of birth, a litter was randomly selected from each mother, their brains dissected and fixed in 10% formalin. Then they were sectioned with 7μm thickness and stained by H.E. Through the use of stereological techniques and systematic random sampling scheme, the volume of the brain and lateral ventricles were estimated. Results: Statistical analyses showed significant increases (p<0.05) in the volume of the brains and lateral ventricles in the experiment group in comparison to the control group. Conclusion: By affecting blood brain barrier permeability in newborn rats, maternal diabetes can generate a large amount of CSF. These effects can bring about brain disorders such as hydrocephalus.
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/05/18

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