Volume 18, Issue 11 (2-2016)                   J Arak Uni Med Sci 2016, 18(11): 19-26 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jodeiry S, Vaziri H R, Zahiri Z. Analysis of ESR1 rs104893956 Polymorphism with Infertility in Guilanian Women. J Arak Uni Med Sci 2016; 18 (11) :19-26
URL: http://jams.arakmu.ac.ir/article-1-3684-en.html
1- Department of Biology, University of Guilan, Rasht, Iran.
2- PhD in Cell and Molecular Biology, Department of Biology, University of Guilan, Rasht, Iran. , vaziri@guilan.ac.ir
3- Department of Gynaecology, Guilan university of Medical Sciences, Rasht, Iran.
Abstract:   (5104 Views)

Background: Infertility is a multifactorial disorder with genetic and non-genomic factors. It is estimated that female infertility factors accounts for more than 40%. Estrogen is one of the effective hormons  in fertility. Its crucial actions on target tissues are mediated via binding to estrogen receptors(ESR). The ESR1 gene is located on chromosome 6q25.1 and encodes α estrogen receptor. The aim of this study was to analysis of ESR1 rs104893956 polymorphism in female infertility.

Materials and Methods: In this case-control study, of 60 infertiles and 55 healthy controls, blood samples were attained. After the extraction of genomic DNA from peripheral blood leukocytes, Allele Specific-PCR (AS-PCR) method was applied for determining the codon polymorphism. Statistical analysis was performed using the MedCalc software (Version 12.1).

Results: The frecuency of T allele was significantly higher in patients (58%) than the controls (44%). There was higher frequency of TT genotype of the polymorphism in patients (18.33%) compared with controls (1.8%). Our findings revealed that the patients carrying the TT genotype had a significant increased risk of infertility.

Conclusion: The results of this study suggests that ESR1 rs104893956 polymorphism may affect the increased susceptibility to female infertility in Guilan province. The results may be different in other genetic pools or large-studied population.

Full-Text [PDF 484 kb]   (1452 Downloads)    
Type of Study: Original Atricle | Subject: Obstetrics & Gynocology
Received: 2015/05/12 | Accepted: 2015/09/12

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb