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URL: http://jams.arakmu.ac.ir/article-1-4367-en.html
2- Department of Cell and Molecular Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran ,
3- PhD of Pharmacology, Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Abstract
Background: Osteoporosis is describesd as a disorder and skeletal disease that decrease bone strength and increases the risk of a bone fractures. Genetic factors have effect role in the progression of the osteoporosis. The aim of this study was to investigate the association between LRP4 gene polymorphism with osteoporosis in a population of postmenopausal women from north of Iran.
Materials and Methods: In this case-control study, 80 female patients with osteoporosis and 80 healthy females without osteoporosis with average age of 45-60 has been investigated. After DNA extraction from genome samples, polymorphism of LRP4 (rs4752947) gene have been investigated by PCR-RFLP method. Data were analyzed by SPSS software.
Results: Our results showed no significant relationship between polymorphism of LRP4(rs4752947) gene and the risk of osteoporosis disease in two patients and control groups. Also, AT genotype and TT genotype compared with AA genotype increased the chance of disease by 1379 and 3.5, respectively. In addition, TT alleles compared with AA alleles, increased the chance of osteoporosis up to 1.605 times.
Conclusion: Of course, more complementary studies considering other LRP4 gene subtypes with more individuals for better findings are needed.
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