Volume 13, Issue 1 (4-2010)                   J Arak Uni Med Sci 2010, 13(1): 119-126 | Back to browse issues page

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Moosavian M, Siahpoosh A, Abbasi E, Darabifar H. The effects of hydro-ethanolic Albizzia lebbeck extract on enteric gram-negative and aerobic gram-positive bacilli. J Arak Uni Med Sci 2010; 13 (1) :119-126
URL: http://jams.arakmu.ac.ir/article-1-447-en.html
1- , moosavian_m@yahoo.com
Abstract:   (15902 Views)
Background: Albizzia lebbeck is used for the treatment of diarrhea and dysentery. In this study the efficacy of hydro-ethanolic extract of this plant on enteric gram-negative and aerobic gram-positive bacillis was determined. Materials and Methods: In this experimental-clinical trial, cold maceration method by ethanol was used for extraction of Albizzia lebbeck fruit, seed, flower and leaves. Then its polyphenolic components were separated by ethyl acetate. After concentrating the different extracts through disk diffusion and tube dilution, the effect of minimal inhibitory concentration (MIC) and minimal bacteriocidal concentration (MBC) of their antibacterial component on shigella dysenteriae, proteus mirabilis, escherchia coli, bacillus cereus and bacillus anthracis were evaluated. Also, the antibacterial effects of Albizzia lebbeck extracts together and in combination with some antibiotics, were compared through variance analysis. Results: Different extracts of Albizzia lebbeck just had similar and positive effects on shigella dysenteriae, bacillus cereus, and bacillus anthracis. However, the hydro-ethanolic fruit extract was more effective than the falavnoid fruit, flower and leave extracts. MIC and MBC results for antibacterial material on the three aforementioned bacterias were 0.125 and 0.25 gram/ml, respectively while the effects of the polyphenolic components of this plant's fruit were similar to its hydro-ethanolic extracts. Conclusion: Through the identification of different components of Albizzia lebbeck and the attainment of new formulations of these components, the grounds will be provided for its application on treatment of patients with inflammatory diseases and asthma, and on improvement of their immune system.
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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2009/09/8

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