Volume 20, Issue 8 (11-2017)
J Arak Uni Med Sci 2017, 20(8): 20-28 |
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Hamidi L, Khatamsaz S, Mokhtari M J, Babaei Beigi M A. The Association of Apolipoprotein A1 Polymorphisms with Diabetes and Hypertension in Patients with Coronary Artery Disease in Fars Province. J Arak Uni Med Sci 2017; 20 (8) :20-28
URL: http://jams.arakmu.ac.ir/article-1-5251-en.html
URL: http://jams.arakmu.ac.ir/article-1-5251-en.html
1- Department of Biology, Faculty of Basic Sciences, Fars Science and Research Branch, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2- Department of Biology, Jiroft Branch, Islamic Azad University, Jiroft, Iran ,saeed1617@yahoo.com
3- Cellular and Molecular Biology, Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran
4- Cardiologist, Department of Cardiology, School of Medicine, Shiraz Branch, University of Medical Sciences, Shiraz, Iran
2- Department of Biology, Jiroft Branch, Islamic Azad University, Jiroft, Iran ,
3- Cellular and Molecular Biology, Department of Biology, Zarghan Branch, Islamic Azad University, Zarghan, Iran
4- Cardiologist, Department of Cardiology, School of Medicine, Shiraz Branch, University of Medical Sciences, Shiraz, Iran
Abstract: (3579 Views)
Abstract
Background: Coronary artery disease (CAD) is a multifactorial disorder, which remains asymptomatic for many years. Genetic and environmental factors are involved to this disease. In the past years , the role of apolipoproteins and their polymorphisms has been identified in the diseases.The aim of this study was to evaluate the correlation between gene polymorphisms of apolipoprotein A1 with diabetes, hypertension and cigarette smoking in CAD sufferers in Fars province.
Materials and Methods: This study evaluates the promoterregion polymorphisms up to intron 2 of APOA1 genes in 75 CAD cases and 75 controls. The method used to determine these polymorphisms was PCR sequencing. This case-control study was performed by odds ratio (OR, with a confidence interval of 0.95) to reveal the association of these polymorphisms with hypertension, diabetes and smoking in CAD patients.
Results: Four polymorphisms were identified in this area. The genotypes of AA in 12718466, GA in rs 670, TC in rs5070 and CC in rs 5069 had the highest frequency in all patient groups and controls. There was a significant association in Rs12718466 between control group with diabetic group (p=0.033).
Conclusion: The results of this study indicated that diabetes, hypertension and cigarette smoking had no effects in initiation and aggravation of CAD.
Background: Coronary artery disease (CAD) is a multifactorial disorder, which remains asymptomatic for many years. Genetic and environmental factors are involved to this disease. In the past years , the role of apolipoproteins and their polymorphisms has been identified in the diseases.The aim of this study was to evaluate the correlation between gene polymorphisms of apolipoprotein A1 with diabetes, hypertension and cigarette smoking in CAD sufferers in Fars province.
Materials and Methods: This study evaluates the promoterregion polymorphisms up to intron 2 of APOA1 genes in 75 CAD cases and 75 controls. The method used to determine these polymorphisms was PCR sequencing. This case-control study was performed by odds ratio (OR, with a confidence interval of 0.95) to reveal the association of these polymorphisms with hypertension, diabetes and smoking in CAD patients.
Results: Four polymorphisms were identified in this area. The genotypes of AA in 12718466, GA in rs 670, TC in rs5070 and CC in rs 5069 had the highest frequency in all patient groups and controls. There was a significant association in Rs12718466 between control group with diabetic group (p=0.033).
Conclusion: The results of this study indicated that diabetes, hypertension and cigarette smoking had no effects in initiation and aggravation of CAD.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/07/31 | Accepted: 2017/09/24
Received: 2017/07/31 | Accepted: 2017/09/24
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